抗原提呈(antigen presentation)是表达于抗原提呈细胞(APC)表面的抗原肽-MHC复合物被T细胞识别,诱导T细胞活化的过程。被提呈的抗原可分为: 外源性抗原(exogenous antigen):来自抗原提呈细胞外,如被吞噬的细胞、细菌。 内源性抗原(endogenous antigen):抗原提呈细胞内合成,如...
根据来源不同可将提呈的抗原分为两大类(图11-1):来源于APC之外的抗原称为外源性抗原(exogenous antigen),如被吞噬的细胞、细菌、蛋白质抗原等;细胞(靶细胞或广义APC)内合成的抗原称为内源性抗原(endogenous antigen),如被病毒感染的细胞合成的病毒蛋白、肿瘤细胞内合成的肿瘤抗原和某些胞内的自身成分等。 根据抗...
Classically, MHC class I and II molecules present endogenous and exogenous antigens, respectively. MHC class II can also present endogenously derived antigens, even though the mechanisms largely remain unclear. In this study, we addressed on the mechanisms of in vivo tolerance induction by peptide-...
Description: This SF1-1.1.1 monoclonal antibody reacts with the H-2Kd MHC class I alloantigen. H-2Kd is involved in antigen presentation to T cells expressing CD3/TCR and CD8. Reactivity to other haplotypes (e.g. b, j, k, p, q, s, and v) has not been observe...
positive regulation of T cell mediated cytotoxicity immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent immune response antigen processi...
Within endosomes, MHC class I assembles with both endogenous and exogenous antigens. • MHC class I is routed from diverse compartments to antigen+endosomes for assembly. • Human MHC class I polymorphisms affect endosomal assembly and surface expression. ...
Antigen presentation via major histocompatibility complex class I (MHC I) molecules is essential to mount an adaptive immune response against pathogens and cancerous cells. To this end, the transporter associated with antigen processing (TAP) delivers sn
molecules and present these at the cell surface. This property is atypical, as most cells exclusively present peptides derived from endogenous proteins on MHC class I molecules. Cross-presentation is essential for the initiation of immune responses to viruses that do not infect antigen-presenting ...
4、a-a、-b、-c presenting endogenous antigen(提呈内源提呈内源性抗原性抗原)2class ii mhc *classical classii mhc : hla- dp 、-dq、- dr presenting exogenous antigen(提呈外源性(提呈外源性抗原)抗原) 3. class iii mhc * c4、bf、c2 、 tnf、hsp70 mhc的特征的特征 高度多态性高度多态性 单体型...
MHC class I molecules, in complex with β-2-Microglobulin (β2 M), are loaded with endogenous peptides generated by the proteasome and imported into the ER by the heterodimeric TAP1/TAP2 transporter. In contrast the MHC class II peptide groove is blocked in the ER by Invariant Chain (Ii...