Tumor aggressiveness and MHC class I and II antigens in laryngeal and breast cancer. Semin Cancer Biol. 1991;2:47- 54.Concha A, Esteban F, Cabrera T, Ruiz-Cabello F, Garrido F. Tumor aggressiveness and MHC class I and II antigens in laryngeal and breast cancer. Semin Cancer Biol 1991...
目前,无论是在基础研究还是在临床上都证实,MHC I(major histocompatibility complex class I,简称MHC I)型肿瘤抗原可以被CD8+细胞毒性T细胞(CD8+cytotoxic T lymphocytes,简称CTLs)所针对识别,从而有效杀伤【5-9】,而识别MHC II型肿瘤抗原的CD4+T细胞是否在肿瘤免疫中起作用呢? 近日,来自美国华盛顿大学圣路易斯分校...
目前,无论是在基础研究还是在临床上都证实,MHC I(major histocompatibility complex class I,简称MHC I)型肿瘤抗原可以被CD8+细胞毒性T细胞(CD8+cytotoxic T lymphocytes,简称CTLs)所针对识别,从而有效杀伤【5-9】,而识别MHC II型肿瘤...
The ability of certain antigen-presenting cells to load peptides that are derived from exogenous antigens onto MHC class I molecules. This property is atypical, because most cells exclusively present peptides from their endogenous proteins on MHC class I molecules. Cross-presentation is essential for...
TCR在T细胞表面通常以多个相同拷贝(>1×105)表达。其中,CD8+T细胞主要识别由I类MHC分子呈递的抗原肽,而CD4+T细胞则主要识别由II类MHC分子呈递的抗原肽。其中:人类MHC→HLA复合体→编码HLA抗原;小鼠MHC→H-2复合体→编码H2抗原。 图1 DC细胞介导的pMHC呈递...
Invitrogen Anti-MHC Class II (I-A/I-E) Monoclonal (M5/114.15.2), eBioscience™, Catalog # 56-5321-82. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL).
et al. Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity. PLoS Comput. Biol. 13, 1–28 (2017). Article Google Scholar Racle, J. et al. Robust prediction of HLA class II epitopes by deep motif deconvolution of ...
Description: The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells. MHC ...
Description: The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells. MHC Class ...
Genetically,therejectionofgraftsdependsonbothMHCandminorHantigen(mH)loci 主要组织相容性复合体（majorhistocompatibilitycomplex，MHC）是位于脊椎动物某染色体上一组紧密连锁的基因群，其编码的分子在启动特异性免疫应答中起重要作用。MHCMHC分子编码蛋白抗原的基因组MHC编码的蛋白分子（抗原）各种动物都有MHC，人类的MHC...