Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure 20, 967–976 (2012). Article CAS PubMed PubMed Central Google Scholar Duan, J. et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering...
The progesterone receptors (PR), PR-A and PR-B, which are both transcribed from a single gene, are not only highly expressed in brain areas associated with reproduction, but also in areas of importance for cognitive function and emotional processing,2 as derived from animal research (Brinton ...
Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium. Am J Physiol Heart Circ Physiol. 2013;305(4):H477–83. https://doi.org/10.1152/ajpheart.00914.2012. Article CAS PubMed PubMed Central Google Scholar Takeda N, Maemura K. The role of ...
active and has physical and psychostimulant activity (Fig 57.1). Sign in to download full-size image FIGURE 57.1.Chemical structure of methamphetamine and related amphetamine compounds. All compounds share chemical structure with dopamine and, therefore, have strong effects on the dopamine system....
Since the striatum is a heterogeneous structure known to exhibit selective vulnerabilities towards different insults, a series of immunohistochemical and cell quantification studies were carried out to identify the phenotypes of cells affected by METH. METH induced death of GABAergic projection neurons. ...
Ballabh P, Braun A, Nedergaard M (2004) The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16:1–13 Bandaru VV, Patel N, Ewaleifoh O, Haughey NJ (2011) A failure to normalize biochemical and metabolic insults during morphine withdrawal disr...
We specifically focused on theDrd1andDrd2genes, which are critical dopamine receptors in the NAc region and play central roles in responding to addictive behaviors for most drugs85. After the METH stimulus, we noticed that the downregulation ofDrd1andDrd2was highly correlated with reduced expressio...
The BBB is a specialized structure responsible for protecting the brain and creating an optimal environment to its normal function. It is constituted by endothelial cells that together with pericytes, astrocytes, basal lamina, microglia, and neurons form the neurovascular unit. Alterations on this ...
Meth decreases the mRNA expression of prefrontal GABAA receptors and transporter Given our previous (Armenta-Resendiz et al.2022) and present findings showing that meth affects pre- and post-synaptic GABAergic activity, we measured mRNA expression of GABAAR and GAT-1—following meth sensitization in...
Systemic administration of METH to mice may exert METH-induced excess catecholamine-mediated indirect effects on the mitochondrial structure and respiration in the hearts of METH-treated mice in vivo (Figs. 6, 7a–e). To obviate the METH-induced neurohumoral impact on the heart and to study ...