the virus replicates within neuronal cells, and the accumulation of viral antigens induces an increase in oxidative stress which leads to the activation of both innate and adaptive immune responses. Viral components are
Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023;624:672–81. Article CAS PubMed Google Scholar Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, et al. Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature. 2023;624:...
Under the microscope, the Sham group rats exhibited normal intestinal structure with intact villi and glands, whereas the I/R group showed noticeable villous edema, shedding, severe glandular damage, breakdown of the lamina propria, significant infiltration of neutrophils, and some areas of bleeding....
Methamphetamine (METH) is a highly addictive drug of abuse and toxic to the brain. Recent studies indicated that besides direct damage to dopamine and 5-HT terminals, neurotoxicity of METH may also result from its ability to modify the structure of blood-brain barrier (BBB). The present study...
Figure 2.1.Mass spectrum of the pentafluoropropionyl (A) and carbethoxyhexafluorobutyryl (B) derivatives ofd-methamphetamine. An ion may be positively charged, in which case the number of electrons in the ion is less than the sum of the number of protons in all nuclei of the ion, or negat...
In the last years, generalization of homologous recombination approaches in the mouse has been extremely fruitful for our general understanding of the molecular mechanisms underlying the acute and chronic effects of psychostimulant drugs. Indeed, this te
Deciphering the structure-immunogenicity relationship of anti-Candida glycoconjugate vaccines. Chem. Sci. 5, 4302–4311 (2014). CAS Google Scholar Wressnigg, N. et al. Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, ...
A longitudinal section of a single human hair obtained through laser microdissection can be directly tested for methamphetamine with the MALDI-TOF-IMS technique. Deep visual proteomics One subcategory of proteomics is spatial proteomics, where protein abundance is correlated with cellular or su...
(Nichols1986). These unique properties distinguish them from other classes of drugs. All entactogens bind to 5-HT1Aand 5-HT2receptors with varying affinities. Some phenethylamines, such as MDMA (3,4-methylenedioxymethamphetamine) and its analogs, affect other monoamines by blocking their uptake ...
the application of methamphetamine (10 μM), DA (100 μM), MDMA (100 μM), β-PEA (100 μM), or tyramine (10 μM) resulted in a robust increase in activated RhoA within 10 min of the addition of drugs (Fig.1c). The ability of these agonists to activate intracellul...