Maladaptive neurological adaptations alter brain structure and function, thereby influencing behavioral control of METH use. Chronic adverse effects of METH are well-known; however, few studies have examined the acute effects on learning and memory. Previous studies developed an early-addiction mouse ...
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Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modelling and docking studies. Chem. Biol. Drug Des. 81, 509–516 (2013). Article CAS PubMed Google Scholar Liao, S., Pino, M. J. Jr., Deleon, C., Lindner-Jackson, M....
active and has physical and psychostimulant activity (Fig 57.1). Sign in to download full-size image FIGURE 57.1.Chemical structure of methamphetamine and related amphetamine compounds. All compounds share chemical structure with dopamine and, therefore, have strong effects on the dopamine system....
Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamine. Group differences in brain structure between methamphetamine-dependent and healthy research participants have been reported, but findings in the literature... AM Morales,B Lee,G Hellemann,....
(b) cross- sectional human studies; (c) a twin study; (d) studies of changes in cognition with abstinence from MA; (e) studies of changes in brain structure and function with abstinence from MA; and (f) studies of the relationship between the severity of MA abuse and the extent of ...
Given that GQD can modulate the gut microenvironment, we examined the gut permeability and inflammatory status in Meth-withdrawn mice. As shown by colon H&E staining (Fig. 1C), both Meth withdrawal and/or GQD did not change the histological structure of colon. By FITC-Dextran detection in...
The pharmacology, behavioral norms, and neurological impact of methamphetamine use present unique challenges to harm reduction approaches. A typical methamphetamine high lasts 8 to 12 hours (a cocaine high lasts only 15 to 30 minutes) and often stretches into a longer "run" during which a user ...
Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy sampl
Psychostimulant methamphetamine (METH) is neurotoxic to the brain and, therefore, its misuse leads to neurological and psychiatric disorders. The gene regulatory network (GRN) response to neurotoxic METH binge remains unclear in most brain regions. Here