Dysfunctional mitochondria accumulate due to diminished turnover via mitophagy which also occurs in myeloid cells, neutrophils, and erythrocytes of patients with SLE. Under metabolic stress, lupus T and B cells accelerate endocytic traffic and autophagy, recycling of proteins into amino acids that ...
Increasing fatty acid oxidation prevents high-fat diet-induced cardiomyopathy through regulating parkin-mediated mitophagy. Circulation 142, 983–997 (2020). CAS PubMed PubMed Central Google Scholar Kolwicz, S. C. Jr. et al. Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents ...
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521, 525–528 (2015). Article CAS PubMed Google Scholar Fang, E. F. et al. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci. ...
mitophagyproteostasissenescencetranslational controlCellular senescence, a stable cell division arrest caused by severe damage and stress, is a hallmark of aging in vertebrates including humans. With progressing age, senescent cells accumulate in a variety of mammalian tissues, where they contribute to ...
Analysis of Pkm mutant mouse lines expressing specific PKM isoforms established that PKM1 boosts tumor growth cell intrinsically. PKM1 activated glucose catabolism and stimulated autophagy/mitophagy, favoring malignancy. Importantly, we observed that pulmonary neuroendocrine tumors (NETs), including small-...
Recent studies have shown that the fidelity of mitochondrial morphology is important in maintaining mitochondrial shape, number, size, membrane potential, ATP synthesis, mtDNA, motility, signaling, quality control, response to cellular stress, mitophagy and apoptosis. This article provides an overview of...
nuclear export [64]. In addition to general autophagy, FoxO3 is involved in the regulation of mitophagy, an autophagy subtype that selectively targets mitochondria. This pathway is mediated by PINK1, a central mitophagy regulator and contributes to the redox homeostasis in the cells [65,66,67]....
mitophagy caused by disruption of the AKT–mTOR–HIF-1α pathway. Capsaicin attenuated phosphorylation of α-synuclein in primary neurons by boosting phagocytosis in PFF-tolerant microglia in vitro. Finally, we found that behavioral deficits and loss of dopaminergic neurons were accelerated in the PFF...
Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable ...
[111]. Studies using LPS and MPTP mouse models have reported similar findings, with pharmacologic activators of mitophagy causing reduced microglial activation and improved DAN viability [112,113]. Taken together, these findings provide strong evidence that mitophagy deficits specifically in microglia can...