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To test the hypothesis that insulin acutely enhances the metabolic clearance rate (MCR) of dehydroepiandrosterone in humans, the effect of a short-term insulin infusion on the MCR of dehydroepiandrosterone was assessed in 10 men and 7 women. After an overnight fast, dehydroepiandrosterone was inf...
Treatment of metabolic acidosis increased both insulin sensitivity and insulin secretion in patients with uremia. This was accompanied by an increase in the circulating levels of 1,25(OH) 2 D 3 but no change in those of parathyroid hormone. 关键词: insulin resistance insulin secretion hemodialysis...
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In this review, we provide an overview of TNF in the context of metabolic inflammation or metaflammation, its discovery as a metabolic messenger, its sites and mechanisms of action and some critical considerations for future research. Although we focus on TNF and the studies that elucidated its...
Thiazolidinediones (TZD) are potent, synthetic ligands for peroxisome proliferator activated receptor-gamma (PPAR-) that reduce plasma nonesterified fatty acids (NEFA) and potentiate the action of insulin in peripheral tissues of several species. Holstein cows (n=9) entering their second or greater ...
Our findings suggest that diminished ERa expression in hematopoietic/myeloid cells promotes aspects of the metabolic syndrome and accelerates atherosclerosis in female mice. 展开 关键词: estrogen action insulin sensitivity DOI: 10.1073/pnas.1104533108 被引量: 77 ...
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nat. Commun. 8, 766 (2017). Article PubMed PubMed Central CAS Google Scholar Field, C. S. et al. Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function. Cell...