Resting memory CD4 T cellsHIV reservoirViral controlThe HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component harboring latent proviruses. This is the first study analyzing the transcriptional profile of...
Unlike memory CD8 T cells and plasma cells, which reside in bone marrow niches, it had been presumed that memory CD4 T cells constantly circulate in the body for surveillance. Now, Tokoyoda and colleagues show that memory CD4 T cells do in fact reside and rest in the bone marrow, where ...
Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152, 2675–2685 (1994). Article CAS PubMed Google Scholar Ndejembi, M. P. et al. Control of memory CD4 T cell recall by the CD28...
In agreement with recent studies, the optimal generation of functional memory CD8 T cells required CD4 help, although long-term maintenance of resting CD8 memory T cells did not absolutely depend on the presence of CD4 T cells. Nonetheless, CD4 T cells were essential during differentiation of ...
CD4+ T cells differentiate and expand during an immune response to a particular invasion. Once infection is cleared, memory Th cells are generated over time following the death of the majority of effector cells. These memory cells can quickly respond to a secondary infection in an antigen-specifi...
Long-lived resting memory CD4+ T cells (TCM) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-TCM cells are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1, and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that com...
Several populations of memory T cells have been described that differ in their migration and function. In this study, we have identified a unique subset of... Bromley,K Shannon - 《Journal of Immunology》 被引量: 127发表: 2013年 CD49b/CD69-Dependent Generation of Resting T Helper Cell Me...
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. In early simian immunodeficiency virus (SIV) and human immunodeficiency virus-1 (HIV-1) infections, gut-associated lymphatic tissue (GALT), the largest com... Li, QS,Duan, LJ,Estes, JD,... -...
Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V (2013) An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic ...
After initial stimulation, naive CD4 T cells make IL-2, which causes the cells to differentiate and may also support their survival and division. Early IL-2 can also programme responding T cells to have an increased capacity for memory survival and function7–9. However, the effect of later...