CD8 T cell memorychromatin remodelingnucleosomeRunx transcription factorstranscriptional elongationviral infectionAdaptive immunity to intracellular pathogens and tumors is mediated by antigen-experienced CD8 T cells. Individual naive CD8 T cells have the potential to differentiate into a diverse array of ...
Characterization of naïve, memory and effector T cells in progressive multiple sclerosis We characterized nave, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4 and CD8 T cells and their expres... BR Nielsen,R Ratzer,L Börnsen,... - 《...
To generate Tmem cells, Zhang et al. adoptively transferred CD8+ OT-I cells, which express a transgenic T cell receptor (TCR) specific for ovalbumin (OVA), into mice infected with an OVA-expressing strain of Listeria monocytogenes. Thirty days post-infection, CD8+ OT-I Tmem cells were ...
While the signals required for the generation of Tmemcells in the respiratory tract are not fully understood, CD8+T cell fate determination is linked strength of TCR signaling, duration of T cell-APC interactions, co-stimulation, and CD4 help6. Moreover, integration of these signals and cytokine...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
In murine models, Thy B cells have been shown to participate in the negative selection of T cells [33]. CD80 and CD86 have been shown to be more highly expressed in PMBL compared with DLBCL [17]. Interestingly, other members of the B7 family are PDL1 and PDL2, which also regulate ...
Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of a novel human mutant TGFβ1/Fc (human IgG4 Fc) fusion protein on memory CD4+ and CD8+ T cell (Tmem) responses in vitro and their recovery following ant...
in CD8 + effector memory (EM) and Th1 cells or Tfh cells (termed “CD8EM/Th-1-rich” and “Tfh-rich”, respectively). The third branch included a mixture of FL and rLN samples appeared to be intermediate in cell composition between the other two branches (termed “mixed”)....
Adoptive transfer, Immunotherapy, T cell, Memory, Effector, Melanoma, CancerBackground Adoptive cell transfer (ACT) is a promising cancer immunotherapeutic strategy that remains ineffective for a large subset of patients. ACT with memory CD8+ T cells (Tmem) has been shown to......
TGF-P availability is altered by infections and cancer; however, the dose-dependent effects of TGF-P on memory CD8 T cell (Tmem) reactivation are still poorly defined. We examined how activation and TGF-P signals interact to shape the functional outcome of Tmem reactivation. We found that ...