The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine lear
These partial losses of function suggest that the essential role of BamD is mediated by its N-terminal region. BamD has no obvious similarity to proteins of known structure, but homologues in Rickettsia spp. and other alphaproteobacteria have been predicted to contain up to six tetratricopeptide ...
Proteins residing in the lipid bilayer of a membrane surrounding a biological compartment make it possible for the compartment to engage in specialized functions. Since the determination of the X-ray structure of the bacterial photoreaction centre, high-resolution structures for more than 15 integral ...
Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty aci...
The first structures, determined 20 years ago, were those of naturally abundant proteins with limited conformational variability, and each membrane protein structure determined was a major landmark. With the advent of complete genome sequences and efficient expression systems, there has been an ...
Detergents can also disrupt the structure and function of membrane proteins, as they interfere with inter- and intra-molecular protein–protein interactions.Of ∼8000 known membrane proteins found in human cells, only ∼50 have a determined structure [2]. With membrane proteins being implicated ...
1). Yet, the field of membrane protein structural biology is in a “log” phase. In recent years much effort has been put toward innovative developments to overcome the numerous obstacles associated with X-ray structure determination of membrane proteins. For instance much progress has been made...
Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions Basement membranes are thin layers of a specialized extracellular matrix that form the supporting structure on which epithelial and endothelial cells grow,... M Paulsson - 《Crc Critical Reviews in Biochemistry》 被引量: 933发表...
The foundation of computational modeling and design tools is the energy function: a mathematical model of the physical rules that distinguish native from non-native membrane protein conformations and sequences. Currently, most computational studies of membrane proteins are molecular dynamics simulations with...
Membrane Structure/ProteinsSpace structuresActive controlDampingSeismic effectsStructural responseThe sections in this article aredoi:10.1002/cphy.cp140103Charles TanfordJacqueline A. ReynoldsJohn Wiley & Sons, Inc.