An estimated 20-30% of proteins in the human genome are membrane proteins, which mediate a broad range of biological processes. Obtaining X-ray crystal structures of membrane proteins has been extremely challenging; fewer than 500 unique membrane protein structures have been deposited in the Protein...
The possible conformations of integral membrane proteins are restricted by the nature of their environment. In order to satisfy the requirement of maximum
In reviewing the structures of membrane proteins determined up to the end of 2009, we present in words and pictures the most informative examples from each family. We group the structures together according to their function and architecture to provide an overview of the major principles and variat...
The main theme of the symposium reported in this book was the presentation and discussion of the direct and indirect evidence available on the three-dimensional structure of membrane proteins and on the interactions relevant to their functioning. Among the topics discussed are the lessons of the kno...
(TROSY). An experiment that enables solution NMR studies of large macromolecules or supramolecular structures, in particular of membrane proteins reconstituted into micelles, bicelles or nanodiscs. Labelling with stable isotopes NMR spectroscopy with complex biomacromolecular systems is routinely based on la...
Mechanisms of Bioenergetic Membrane Proteins: Structures and BeyondStudies of biological sciences can be approached in two ways: reductively, as in molecular biology, or holistically, as in systems biology. In this paper, I illustrate my views on approaches to bioenergetics through the analysis of ...
Folding DNA into a lipid-conjugated nanobarrel for controlled reconstitution of membrane proteins. Angew. Chem. 57, 2072–2076 (2018). Article CAS Google Scholar Martin, T. G. et al. Design of a molecular support for cryo-EM structure determination. Proc. Natl Acad. Sci. USA 113, E7456...
High-resolution Structures of Protein-Membrane Complexes by Neutron Reflection and MD Simulation: Membrane Association of the PTEN Tumor Suppressor The lipid matrix of biomembranes is an in-plane fluid, thermally and compositionally disordered leaflet of 5 nm thickness and notoriously difficult to characte...
A synopsis of the 2007 annual progress report for the Center for Structures of Membrane Proteins, a specialized center of the Protein Structure Initiative.doi:10.1007/s10969-008-9058-3Robert M. StroudSenyon ChoeJames HoltonH. Ronald Kaback
Integral membrane proteins are involved in a wide range of essential biological functions and the determination of their three-dimensional structures plays