The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine lear
BamC also lacks significant similarity to any protein of known structure, suggesting that it possesses novel folds or features. BamE is present in all alpha-, beta- and gammaproteobacteria. Although BamE is not an essential BAM subunit, null mutants exhibit OMP folding defects and increased ...
To each amino acid residue one attributes a potential for α-helix, β-strand, and β-turn conformation, which has been deduced from proteins of known three-dimensional structure. For a protein of unknown structure, the profiles of the three potentials along the amino acid sequence are compared...
control a wide range of protein functions, but their design has been neglected owing to a lack of accurate computational tools. Now it is shown that allosteric signalling membrane proteins can be engineered through such networks, revealing a broader space of designable protein interactions and ...
The first structures, determined 20 years ago, were those of naturally abundant proteins with limited conformational variability, and each membrane protein structure determined was a major landmark. With the advent of complete genome sequences and efficient expression systems, there has been an ...
This structure has made an enormous contribution not only to biology but also to drug discovery by revealing the mechanism of action of GPCRs at the molecular level. However in spite of recent successes, the path to a high-resolution structure of a membrane protein still involves several ...
An alternative is to directly calculate amino acid preferences by deriving statistical potentials from a database of known membrane protein structures (33, 34, 35, 36). Yet, statistical potentials do not capture varying physiochemical properties of the membrane. In this work, we developed a ...
The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA cloning - ScienceDirect Revel J-P and Horwitz J ( 1984 ) The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA clo......
Membrane proteins are proteins that are embedded among the phospholipids that make up the bilayer structure of cell membranes. The membrane protein performs specific tasks that are essential for the proper functioning of the cell. These include transporting molecules and ions into and out of the cell...
Structure of a nascent membrane protein as it folds on the BAM complex Cryo-electron microscopy structures of a folding intermediate on the BAM complex of Escherichia coli reveal how interactions between the BamA catalyst and substrate permit stable association during folding, followed by rapid turn...