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the global analysis of these proteins has proved to be difficult. A greater effort has thus been undertaken to develop prediction methods, with reasonable success [2–4]. Most of these have been devised to detect transmembrane segments with an α-helical conformation...
Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty aci...
Structure of an endogenous mycobacterial MCE lipid transporter Proteins of the Mycobacterium smegmatis Mce1 system assemble to form an elongated ABC transporter complex that is long enough to span the impermeable mycobacterial cell envelope. James Chen , Alice Fruhauf & Damian C. Ekiert Article |...
Many high-resolution 3D structures of integral membrane proteins have proven to be fundamental for a better understanding of many biological processes [9], [10], [11]. Most recently the crystal structure of the beta2 adrenergic receptor in complex with the G protein was solved by Kobilka's ...
Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions Basement membranes are thin layers of a specialized extracellular matrix that form the supporting structure on which epithelial and endothelial cells grow,... M Paulsson - 《Crc Critical Reviews in Biochemistry》 被引量: 933发表...
Membrane proteins are proteins that are embedded among the phospholipids that make up the bilayer structure of cell membranes. The membrane protein performs specific tasks that are essential for the proper functioning of the cell. These include transporting molecules and ions into and out of the cell...
structure of eukaryote proteins to their sequence homologs in bacteria opens an avenue where determination of three-dimensional structure of abacterial proteinprovides a reasonable model for the structure of its mammalian homolog, and can reinforce ideas about the structure-activity relationship of the ...
About one-quarter of all our proteins protrude through a membrane. This makes them important communicators both in cellular compartments and outside the cell, but it also makes their structure more difficult to determine, which in turn makes their precise mode of action harder to understand. Sever...