Figure3shows the mean and variance of Se, Sp, Mcc, F-m, OA and G-m for each membrane protein type under the CapNet, OCNN and ICNN models. The OA of the ICNN was higher than that of the other models, and the prediction performance for each type exhibited a smaller variance in dif...
membrane protein typesjackknife cross-validationThe membrane protein type is an important feature in characterizing the overall topological folding type of a protein or its domains therein. Many investigators have put their efforts to the prediction of membrane protein type Here, we propose a new ...
It is thus highly desirable to develop an automated method that can serve as a high throughput tool in identifying the types of newly found membrane proteins by their primary sequence information only. In this paper, features are extracted from membrane protein sequences using pseudo-amino acid (...
(2007) Prediction of membrane protein types from sequences and posi- tion-specific scoring matrices. J Theor Biol, 247, 259-265.Pu, X.; Guo, J.; Leunga, H.; Lin, Y.L. Prediction of membrane protein types from sequences and position-specific scoring matri- ces. J. Theor.l Biol.,...
Rapid membrane protein topology prediction. Summary: State-of-the-art methods for topology of 伪-helical membrane proteins are based on the use of time-consuming multiple sequence alignments obtained... Hennerdal,Aron,Elofsson,... - 《Bioinformatics》 被引量: 82发表: 2011年 Crossflow microfiltratio...
[IEEE 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) - Shanghai, China (2013.12.18-2013.12.21)] 2013 IEEE International Conference on Bioinformatics and Biomedicine - A hybrid approach to recognising discours... Mihaila, Claudiu,Ananiadou, Sophia 被引量: 1发表: 2013年...
proteins. Alternatively, a membrane protein can be monotopic and anchoredviaan amphipathic helix inserted in a parallel way to the membrane interface, so-called in-plane membrane (IPM) anchors. This type of membrane anchor is still poorly understood and no suitable prediction method is currently ...
Adamian L, Liang J: Prediction of buried helices in multispan alpha helical membrane proteins. RANTS: http://gila.bioengr.uic.edu/lab. Proteins 2006, 63: 1–5. 10.1002/prot.20874 Article CAS PubMed Google Scholar White SH: The progress of membrane protein structure determination. Protein ...
(Supplementary Fig.2b, c). Subsequently, we utilized these selected PPI templates to infer MP-interacting protein candidates by evaluating theirSSIMvalues by searching the complete human proteome database (UniProt12; Supplementary Fig.2d). We compared the PPI prediction accuracies of ourSSIM, six ...
The outer membrane is a formidable barrier that protects Gram-negative bacteria against environmental threats. Its integrity requires the correct folding and insertion of outer membrane proteins (OMPs) by the membrane-embedded β-barrel assembly machiner