Arnold I, Langer T 2002 Membrane protein degradation by AAA proteases in mitochondria. Biochim Biophys Acta 1592:89-96Arnold I, Langer T. Membrane protein degradation by AAA proteases in mitochondria. Biochim Biophys Acta 2002; 1592:89-96....
Targeted protein degradation is a promising drug discovery approach. A study now describes transferrin receptor targeting chimeras (TransTACS), which lysosomally degrade membrane proteins with potent specificity and efficacy. TransTACs reversibly regulate the tumor-killing activity of CAR-T cells and inhib...
4,5), we developed transferrin receptor targeting chimeras (TransTACs), a heterobispecific antibody modality for membrane protein degradation. TransTACs are engineered to drive rapid co-internalization of a target protein of interest and TfR1 from the cell surface, and to enable target protein ...
A. Mechanistic insights into ER-associated protein degradation. Curr. Opin. Cell Biol. 53, 22–28 (2018). CAS PubMed PubMed Central Google Scholar Christianson, J. C. & Ye, Y. Cleaning up in the endoplasmic reticulum: ubiquitin in charge. Nat. Struct. Mol. Biol. 21, 325–335 (...
We used the conserved INM protein SUN1 as a model to dissect the functional connection between the INM-CDC48 association and INM protein degradation in plants. We showed that SUN1 undergoes constitutive degradation in a proteasome-dependent and autophagy-independent manner in Arabidopsis, and this ...
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane . J Biol Chem 286 : 19630–19640... SR Yoshii,C Kishi,N Ishihara,... - 《Journal of Biological Chemistry》 被引量: 591发表: 2011年 Yeast mitochondrial outer membrane specifically binds cytopla...
Protein degradation was investigated in three different states of differentiation: (a) in normal liver, (b) in regenerating liver, and (c) in the Morris hepatomas 7777, 3924A and 9121. Rate constants of degradation (kd) and half-lives (t1/2) of protein were determined in the plasma memb...
ERAD responds to environmental cues to regulate the proteasomal degradation of specific ERAD substrates according to cellular need. In this review, we discuss in detail seven proteins that are targeted by the ERAD quantity control system. Not surprisingly, ERAD-mediated protein degradation is a key ...
(Fig. 1c,d). Using this approach, we could demonstrate a time-dependent increase of membrane protein internalization; at 2 h∼15% of the total cell-surface proteome was internalized, and then showed a decline at 8 h to∼10% probably due to protein degradation (Fig. 1e). To ...
The protein family initially discovered was named porins, as they form pores for the uptake of solutes. They were considered to be unspecific for small solutes and thereby gave an impression of a molecular sieve behavior of the outer membrane. Research in recent decades, however, challenged this...