We used the conserved INM protein SUN1 as a model to dissect the functional connection between the INM-CDC48 association and INM protein degradation in plants. We showed that SUN1 undergoes constitutive degradation in a proteasome-dependent and autophagy-independent manner in Arabidopsis, and this ...
A novel transiently expressed, integral membrane protein linked to cell activation. Molecular cloning via the rapid degradation signal AUUUA. Author links open overlay panelH.W. Gaugitsch, E.E. Prieschl, F Kalthoff, N.E. Huber, T BaumrukerShow more Add to Mendeley Share Cite...
Lysyl ubiquitination has long been known to target cytoplasmic proteins for proteasomal degradation, and there is now extensive evidence that ubiquitinatio... JN Hislop,MV Zastrow - 《Traffic》 被引量: 153发表: 2011年 Protein kinase C and the regulation of glutamate exocytosis from cerebrocortical ...
Janus kinase-signal transducer and activator of transcription pathway Effector pathway by which IL-6 exerts its pathogenic effects in CSDH Cyclooxoygenase 2 (COX-2)–prostaglandin E2 (PGE2) pathway COX-2 triggers the synthesis of PGE2 from arachidonic acid, which in turn stimulates the overexpress...
A multiprotein E3 ubiquitin ligase that targets cell cycle proteins for proteasomal degradation. Cortex An actin-rich layer immediately underneath the plasma membrane that plays important roles in cell shape control. Membrane blebbing The bulging of the cell membrane that protrudes into the extracellular...
Protein PhosphorylationSignal TransductionThe susceptibility of purified protein kinase C to oxidative inactivation by H2O2 was found to be increased by Ca2+ ... R Gopalakrishna,Anderson, W. B - 《Proc Natl Acad Sci U S A》 被引量: 957发表: 1989年 Phospholipid degradation and signal translation...
Misfolded proteins in the endoplasmic reticulum (ER) are eliminated by a quality control system called ER-associated protein degradation (ERAD). However, i... Foresti,Ombretta,Rodriguez-Vaello,... - 《Science》 被引量: 70发表: 2014年 Exposure of bipartite hydrophobic signal triggers nuclear quali...
(Novus Biologicals, NB100-2220) with a ratio of 1:5000. To quantify the LC3-II expression level, western blot experiments were performed 4 times. The signal intensity of LC3-II was measured using Image Studio version 5 software (LI-COR Biotechnology), then normalized to the intensity of β...
This structure together with the Arrival Complex suggests that SurA binds POTRA-1 first prior to the OMP β-signal engagement with BamA β1. The release complexes The SurA-OmpX construct disulphide bonded at ΒamA-β1 may have captured an early folding intermediate of OmpX on BAM, but OmpX...
The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles. EMBO J. 15, 5230–5239 (1996). Article CAS PubMed PubMed Central Google Scholar Hunziker, W. & Geuze, H. J. Intracellular trafficking of lysosomal membrane proteins. Bioessays...