megakaryopoiesisthrombopoiesisAutophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various ...
causes impaired platelet production and activationThe failure in platelet production and activation in autophagy-defective mice results primarily from impaired megakaryopoiesis and thrombopoiesisImpaired megakaryopoiesis and thrombopoiesis are caused by mitochondrial and cell-cycle dysfunction due to autophagy ...
Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.doi:10.1111/bph.14031The poor prognosis of acute megakaryoblastic leukaemia (AMKL) means there ...
Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice. Experimental hematology 43, 488-494 (2015).Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice[J] . Yan Cao,Jinyang Cai,Su...