Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction, including of bone destruction in the jaws. Osteonecrosis of the jaws can be caused by two pharmacological agents: antiresorptive (including bisphosphonates (BPs) and receptor activator of nuclear factor kappa-B ...
Two decades ago, Marx described medication-related osteonecrosis of the jaw (MRONJ) as an emerging clinical entity in patients receiving bisphosphonate therapy [3,4]. MRONJ is now an established condition defined by exposed bone that can be probed through an intra- or extra-oral fistula(e) in...
Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face new...
bisphosphonate‐related osteonecrosis of the jawhypercalcemiaosteomyelitispamidronateA 12‐year‐old, neutered female, domestic medium hair cat was evaluated for a nonhealing, oral mucosal ulceration. The cat had a history of idiopathic hypercalcemia that had been treated with a bisphosphonate for 41...
Medication‐related osteonecrosis of the jaw (MRONJ) is developed even in the patients who are edentulous and treated with short‐term bisphosphonate therapy and oral administration. It sometimes causes lethal sepsis in patients who have multiple health problems such as diabetes, cirrhosis, steroid ...
Medication-related osteonecrosis of the jaw (MRONJ) is a major problem that can occur in people taking certain medications such bisphosphonates and denosumab. It can be used to treat osteoporosis or cancer. Bisphosphonate exposure, dental diseases and procedures, age, sex, anatomical factors, medical...
Medication-related osteonecrosis of the jaw and phosphorous necrosis are strikingly similar. Phosphorous necrosis (phossy jaw) was caused by close contact with yellow phosphorous. In the nineteenth century, the knowledge concerning cause and prevention of osteonecrosis was astonishingly accurate. Rules conc...
Purpose: The aim of this study was to present the current concept of bone quality based on the proposal by the National Institutes of Health (NIH) and some of the cellular and molecular factors that affect bone quality. Study selection: This is a literature review which focuses on collagen,...
Medication-related osteonecrosis of the jaw (MRONJ) is primarily an adverse side effect of denosumab or bisphosphonates (particularly when used at high doses to prevent skeletal-related events [SREs] in patients with cancer and bone metastases) or possibly anti-angiogenic cancer treatment. While the...
Medication-related osteonecrosis of the jaw associated with aflibercept. The British journal of oral & maxillofacial surgery. 2017;55(3):314-5.Zarringhalam P, Brizman E, Shakib K. Medication-related os- teonecrosis of the jaw associated with aflibercept. Br J Oral Maxillofac Surg. 2017;55:...