Bisphosphonate related osteonecrosis of the jaw is a disease that is difficult to treat. For patient it costs too much, not because of using the expensive antibiotics, but mostly because it leads to the defects in patient's jaw, it is affecting the oral intake and the life of the patient ...
Osteonecrosis also occurs with bone-binding antimetabolites, and bisphosphonate osteonecrosis, particularly of the jaw, is an important problem where type and length of treatment affect likelihood of the complication. Sclerotic disorders generally reflect local or systemic changes in bone morphogenetic ...
Prosthodontists and surgeons continue to face various challenges because of this condition [[1], [2], [3], [4]]. Conservative therapy, such as treatment of exposed necrotic bone with antibiotics and mouthwash [5] or hyperbaric oxygen [6], and jaw resection and reconstruction [7] are ...
Osteonecrosis of the jaw (ONJ), also known as “dead jaw syndrome,” Avascular Necrosis and Aseptic Necrosis, is a rare but serious condition involving severe loss or destruction of the jawbone. ONJ disrupts the blood supply to the jawbone. This causes tiny breaks that can lead to total bo...
It is well established that alterations in phosphate metabolism have a profound effect on hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the jaw (ONJ) was preceded by phosphorus necrosis of the jaw, ca. 1860.
Bisphosphonates are the first-line drugs for osteoporosis, as well as for many types of cancer.One of their side-effects is osteonecrosis of the jaw, which has mainly been associated with their intravenous administration.This article features a clinical study of 21 cases of jaw osteonecrosis – ...
The duration of therapy varied from 12 to 77 months before osteonecrosis was observed; 92% (11/12) of cases involved the posterior mandible and all cases have been refractory to a variety of medical therapies, including surgical debridement and systemic antibiotics. Available tissue biopsies ...
ONJ is an area of exposed necrotic bone in the mandible or maxilla persisting for more than eight weeks in a patient receiving bisphosphonates. The results revealed the need for long-term courses of antibiotics for such patients suggesting preventive dentistry helpful in reducing the prevalence of ...
Medication-related osteonecrosis of the jaw (MRONJ) is a major problem that can occur in people taking certain medications such bisphosphonates and denosumab. It can be used to treat osteoporosis or cancer. Bisphosphonate exposure, dental diseases and procedures, age, sex, anatomical factors, medical...
Denosumab was discontinued by the oncologist, and oral antibiotics with rinsing of the exposed bone area were prescribed. By 36 weeks after discontinuation of denosumab, a sequestrum in the posterior part of the mandible was naturally shed, and the site was healed. Bisphosphonate is deposited in ...