Mechanistic target of rapamycin in common carp: CDNA cloning, characterization, and tissue expression[J].Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function 2013,2(2).Jiang, J. , Feng, L. , Liu, Y. , Jiang, W.D. , Hu, K. , Li, S.H. & Zhou,...
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP and Duggavathi R: Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice. Mol Reprod Dev 81: 655‑665, 2014.Dayananda Siddappa , Anitha Kalaiselvanraja , Vilceu Bordignon ,...
mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast grow.机械的雷帕霉素靶1是一个重要的中介复杂的代谢和纤维母细胞生长 热度: Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus. 热度: Selective ...
With each contraction-relaxation cycle, a satellite cell is expected to experience tensile, shear, and compressive stresses, and through cell-extracellular matrix interactions, also gauge the stiffness of the niche. Via mechanoreceptors, cells can sense these......
We describe the relationship between the mechanistic target of rapamycin complex 1/2 protein subunit regulatory associated protein of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncogene homolog 1 (AKT1), and the protease cathepsin H (CTSH), for which...
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR). As a nutrient sensor, mTOR has important homeostatic functions to regulate energy metabo...
We hypothesized that mechanistic Target of Rapamycin Complex 1 (mTORC1) is a positive regulator of key genes encoding Electron Transport Chain (ETC) proteins and stimulates oxidative phosphorylation in trophoblast and that ETC protein expression is down-regulated in placentas of infants with ...
mitochondria mechanistic target of rapamycin 1 (mTORC1) signalMetformin exhibits antiproliferative and proapoptotic effects in a variety of diseases, characterized by malignant and nonmalignant hyperplastic cells; however, the underlying molecular mechanism of metformin in psoriasis has not been elucidated. ...
This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this speci...
Mechanistic Target of Rapamycin The mechanistic target of rapamycin (mTOR) is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription, and effective pharmacologic inhibitors such as rapamycin (and its analogues, ...