Results We identified the mechanistic target of rapamycin (mTOR) pathway as a potential therapeutic target in KD. The mTOR inhibitor rapamycin potently inhibited cardiac fibroblast proliferation in vitro , and vascular fibroblasts up‐regulated mTOR kinase signaling in vivo in the CAWS mouse model of ...
Antipsychotic pharmacotherapy has been widely recommended as the standard of care for the treatment of acute schizophrenia and psychotic symptoms of other psychiatric disorders. However, there are growing concerns regarding antipsychotic-induced side effects, including weight gain, metabolic syndrome (MetS),...
Mechanistic Target of Rapamycin: Pathways and Regulation mTORC1 The mTOR complex 1 (mTORC1) is comprised of the 289 kDa mTOR serine-threonine kinase, its rapamycin-sensitive regulatory protein Raptor, as well as three other proteins: GβL/mLST8, a 40 kDa proline-rich Akt substrate (PRAS40)...
世联博研公司现货供应ANTIBODIES-ONLINE GmbH品牌订货号为ABIN1513366的Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448) Antibody from ANTIBODIES-ONLINE GmbH产品
In this study, we demonstrate that PKCδ, a STAT1 kinase, contains a functional ‘target of rapamycin signaling’ (TOS) motif that directs its interaction with mTORC1. Depletion of KPNA1 by RNAi prevented the nuclear import of PKCδ in cells exposed to the mTORC1 inhibitor rapamycin or ...
Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat-stressed... Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat...
We demonstrated that LMP2A reinforces the expression of MTA1 via the mechanistic target of rapamycin (mTOR) pathway to promote EMT in NPC. Furthermore, by knocking down 4EBP1 in combination with the new mTOR inhibitor INK-128 treatment, we discovered that LMP2A expression activates the 4EBP1...
mTOR Mammalian target of rapamycin MMP Matrix metalloproteases MPQ McGill Pain questionnaire spasticity MOSSS sleep Medical outcomes study (MOS)-sleep scale MCS Mental component summary MDA Malondialdehyde MEK Mitogen-activated protein kinase kinase MBPI Modified version of the BPI MORs Morphine receptors ...
Given its involvement in tumour development and progression, the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway has emerged as a promising therapeutic target in GBM. The PI3K/AKT/mTOR signalling network is known to be activated in nearly 90% of GBM patients [...
11. Mechanistic target of Rapamycin (mTOR) 12. VEGF 13. ROCK1 14. FOXC2 15. Kruppel-like factor 12 (KLF12) 16. LIMK1/Cofilin1 pathway 17. SRY-box proteins (SOX) 18. NLRP3 19. Concluding remarks Declaration of competing interest References Cited by (8) Figures (3)Non...