mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast grow.机械的雷帕霉素靶1是一个重要的中介复杂的代谢和纤维母细胞生长 热度: Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus. 热度: Selective ...
This special issue on mammalian target of rapamycin (mTOR) explores the importance of mTOR in cell growth control and cancer. Cancer cells often exploit mTOR as a mechanism to enhance their capacity to grow. While protein synthesis is by far the best-characterized mTOR-driven process, this speci...
Mechanistic Target of Rapamycin (mTOR): Integrating Growth Factor and Nutrient Signaling in the Collecting Duct 来自 国家科技图书文献中心 喜欢 0 阅读量: 18 作者:B Aaron,MB Fluitt,CM Ecelbarger 摘要: The kidneys are a vital pair of bean-shaped organs in the lower back primarily involved in ...
The mechanistic target of rapamycin (mTOR) is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription, and effective pharmacologic inhibitors such as rapamycin (and its analogues, so-called rapalogues) have bee...
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR). As a nutrient sensor, mTOR has imp
篇名 Stem cell guidance through the mechanistic target of rapamycin 来源期刊 世界干细胞杂志:英文版(电子版) 学科 医学 关键词 Apoptosis AUTOPHAGY Cancer Cardiovas- cular Erythr 年,卷(期) 2015,(7) 所属期刊栏目 研究方向 页码范围 999-1009 页数 11页 分类号 R96 字数 语种 DOI 相关学者/机构...
Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythe... Perl, "Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+CD4-CD8- double-negative T cells and contracts regulatory T ...
We hypothesized that mechanistic Target of Rapamycin Complex 1 (mTORC1) is a positive regulator of key genes encoding Electron Transport Chain (ETC) proteins and stimulates oxidative phosphorylation in trophoblast and that ETC protein expression is down-regulated in placentas of infants with ...
Recent studies have demonstrated that the mechanistic/mammalian target of rapamycin (mTOR) pathway plays a critical regulatory role in the pathophysiology of antipsychotic drug-induced disorders of hepatic glucose and lipid metabolism. Furthermore, antipsychotic drugs promote striatal mTOR pathway activation ...