Novel mechanisms of STAT protein regulationdoi:10.1111/j.1432-1033.2004.04463.xThomas MeyerUwe VinkemeierJohn Wiley & Sons, Ltd (10.1111)European Journal of Biochemistry
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2, 326–332 (2000). This study indicates that BiP is involved in the regulation of the UPR. CAS PubMed Google Scholar Karagoz, G. E., Acosta-Alvear, D. & Walter, P. The unfolded...
Sumolyation is a post-translational modification that involves the attachment of SUMO proteins (SUMO1, SUMO2 or SUMO3), small ubiquitin-like peptides, to lysine residues that lead to different aspects of protein regulation and/or function. SUMO proteins are attached to targets in an analogous ...
3. Gould N, Doulias PT, Tenopoulou M, Raju K,Ischiropoulos H. Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem. 2013;288:26473-9.4. Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, et al. METABOLISM. S-Nitrosylation links obe...
protein synthesis and maturation [3]. As a folding catalyst, the PDI proteins are capable of preserving the native conformation and stability of other proteins via the formation, isomerization and rearrangement of disulfide (S–S) bonds. The formation of S–S bonds between two cysteine residues ...
Together, this work defines the evolutionarily conserved repression mechanism of PUF proteins via deadenylation, decay and translational repression via Pabp. 展开 关键词: RNA Binding Protein PUF Protein EIF-4E Binding Protein Post-transcriptional MRNA Regulation ...
(ECM) protein synthesis [14,15]. In fibrotic diseases, the exact mechanism of GPNMB involvement in the inflammatory response is unclear; however, it is known to be involved in the progression of fibrosis through upregulation of MMP-3 mRNA expression in mouse fibroblasts, which activates the ...
T. Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation. J. Biol. Chem. 272, 28036–28041 (1997). Article CAS PubMed Google Scholar Nicholson, K. L. et al. Regulation of SNARE complex assembly by an N-terminal ...
Traditional drug discovery mainly focuses on direct regulation of protein activity. The development and application of protein activity modulators, particularly inhibitors, has been the mainstream in drug development. In recent years, PROteolysis TArgeti
2. Basic Pharmacology of BoNT/A: Mechanisms of Outstandingly High BoNT/A Potency and Long-Lasting Duration of Action To describe how the effect of BoNT/A persists for months after its single use, it is important to understand the structure and function of the different toxin protein subunits,...