Because of their phagocytic activity and their ability to differentiate into antigen-presenting cells, monocytes participate in both innate and adaptive immune responses. They derive from bone-marrow progenitor cells, circulate in the blood as monocytes
et al. Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus. Cell 176, 1420–1431.e17 (2019). Article CAS Google Scholar Maugeri, M. et al. Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport ...
23 However, E2F1 protein levels were not significantly changed in ccRCC cells (Figure S4D). Considering that the phosphorylation of retinoblastoma 1 (RB) is crucial to E2F transcription factor activity,24 we detected the phosphorylation of RB at S795 and S807/811 after silencing MEX3A in ccRCC...
3.5.2. Effect of DEHP, DBP, and their mixture on protein expression of the PI3K/Akt/Bcl-2 signaling pathway The relative protein levels of Bax, cleaved-Caspase 9, Caspase 8, and cleaved-Caspase 3 in the DEHP, DBP, and DEHP+DBP groups increased, but the relative protein levels of PI3K...
(B) TRPV4 protein expression level in different human cancerous and adjacent non-cancerous/normal tissue in terms of The Human Protein Atlas. (C) Strong immunoreactivity was observed in melanoma patients. (D) Representative images of TRPV4 expression (green) in multiple cells (Above: Skin-...
They belong to the major intrinsic protein (MIP) superfamily. There are 33 MIP (four incompletes) sequences identified in grapevine [34,35,36,37]. MIPs are divided into several families. The plasma membrane intrinsic proteins (PIPs) and the tonoplast intrinsic proteins (TIPs) are the most ...
*Plant height (PH), Shoot fresh weight (SFW), Shoot dry weight (SDW), Leaf number (LN), Leaf area (LA), Flower diameter (FDI), Internode length (EN), Relative Water Content (RWC), Proline (Prol), Protein (Prot), Total chlorophyll (ChT), Carotenoid (CAR), Malondialdehyde (MDA),...
Therefore, mammalian sirtuins, directly controls the activity of metabolic enzymes through reversible lysine acetylation. Modifiers of activity or acetylation status of AceCS2 is a useful type II diabetes, hypercholesterolemia, hyperlipidemia, and obesity, etc., in the treatment of pathological conditions....
Proliferating cell nuclear antigen (PCNA) forms a trimeric ring that associates with and influences the activity of many proteins participating in DNA metabolic processes and cell cycle progression. Previously, an uncharacterized small protein, encoded by TK0808 in the archaeon Thermococcus kodakarensis, ...
Further work will focus on the p38 activity in gastric cancer and the role of p38 pathway in gastric cancer tumorigenesis and metastasis. Alterations in the upstream signals could lead to subsequent alterations within the intracellular phosphorylation cascade. Our data show that the protein level of ...