regulation of monomers, multimers, oligomeric subunits and oligomers, or proteins by changing their form and function sufficiently, to yield a new set of interaction rules which closely resemble the rules followed by naturally occurring monomers, multimers, oligomeric subunits oligomers and proteins. This...
The effects of confounding factors on gene expression analysis have been extensively studied following the introduction of high-throughput microarrays and subsequently RNA sequencing. In contrast, there is a lack of equivalent analysis and tools for RNA
While aiding the design of selective binders, the low abundance of cysteine also presents a problem and excludes many potential targets. In the case of 14-3-3 proteins, the different isoforms are highly similar in sequence and there is some degree of functional redundancy in their activity56,57...
Incidentally, this indicates that there is no post-translational regulation of the ppc gene. It is known that the untranslated sequence at the 5' end of mRNA, beyond its role in engaging ribosomes, is important for the stability of the transcript. Changes in this sequence may therefore affect...
In metazoan genome, the mechanism of gene expression regulation between transcriptional regulatory elements and their target gene is spatiotemporal. Active promoters possess many specific chromosomal features, such as hypersensitive to DNaseI and enrichment of specific histone modifications. In this article,...
Developmental process, anatomical structure development, cellular response to stress, response to oxidative stress, positive regulation of lymphocyte activation, and limb morphogenesis were additional enriched gene ontology terms from the GenSel results (Additional file3 contains the complete list)....
Cryo-electron tomography (cryo-ET) is widely used to explore the 3D density of biomacromolecules. However, the heavy noise and missing wedge effect prevent directly visualizing and analyzing the 3D reconstructions. Here, we introduced REST, a deep learni
Spatially resolved transcriptomics provides the opportunity to investigate the gene expression profiles and the spatial context of cells in naive state, but at low transcript detection sensitivity or with limited gene throughput. Comprehensive annotating
Several cis-acting regulatory sequences functioning at the level of mRNA or nascent peptide and specifically influencing transcription or translation have been described. These regulatory elements often respond to specific chemicals. We have developed a
Developmental process, anatomical structure development, cellular response to stress, response to oxidative stress, positive regulation of lymphocyte activation, and limb morphogenesis were additional enriched gene ontology terms from the GenSel results (Additional file3 contains the complete list)....