Calcium (Ca2+) is an essential nutrient for plants and a cellular signal, but excessive levels can be toxic and inhibit growth1,2. To thrive in dynamic environments, plants must monitor and maintain cytosolic Ca2+ homeostasis by regulating numerous Ca2+ transporters3. Here we report two signalli...
Mechanisms of calcium homeostasis in the polymorphonuclear leucocyte . Agents and Actions , 19 , 81 – 86 .WESTW~CK,J., and C. POLL. 1986. Mechanisms of calcium homeostasis in the polymorpho- nuclear leucocyte. Agents Actions 19:80.
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Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases such as neurodegenerative diseases and cancers. The cellular cholesterol level reflects the dynamic balance between...
Transient receptor potential (TRP) channels, which are a class of cation channels, are widely expressed cation channels that play an important role in mediating calcium homeostasis and are considered to be potential regulators of inflammatory pain. Skeletal disorders with increased bone resorption by os...
Exposure to space radiation leads to the generation of ROS, which disrupts calcium homeostasis in cardiac cells by inhibiting LTCC and NCX in the cell membrane of cardiomyocytes as well as SERCA in the membrane of sarcoplasmic reticulum (SR). ROS can also cause DNA damage and oxidative ...
The most important mechanisms of diabetic cardiomyopathy are metabolic disturbances (depletion of glucose transporter 4, increased free fatty acids, carnitine deficiency, changes in calcium homeostasis), myocardial fibrosis (association with increases in angiotensin II, IGF-I, and inflammatory cytokines), ...
Therefore, the relative overexpression of Na +/Ca 2+ exchangers in muskrat hearts may be beneficial in the preservation of contractile function and calcium homeostasis in this freshwater diving mammal. 展开 关键词:Heart Hypoxia Calcium Sodium–calcium exchanger Ryanodine ATPase ...
TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6 inhibitors are needed for the treatment of a broad range of diseases associated with disturbed calcium homeostasis, including cancers. Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular ...
et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 19, 1013–1026 (2012). CAS PubMed PubMed Central Google Scholar Chae, H. J. et al. BI-1 regulates an apoptosis ...