Mechanism of gonadotropin gene expression. Identification of a novel negative regulatory element at the transcription start site of the glycoprotein hormone alpha-subunit gene. J Biol Chem. 2002; 277 (43):40235–40246. doi: 10.1074/jbc.M207177200. [ Cross Ref ]...
respectively, accordant with the formation of a NanR-dimer1/DNA hetero-complex. Integrating the co-migrating peaks between 6 and 7.25 S gave molar ratios of 3.63:1 and 4.65:1 (Fig.3b–d), consistent with a NanR-dimer2/DNA hetero-complex. As the concentration of NanR was increased ...
The first report of a gene defect that causes ALS. Article ADS CAS PubMed Google Scholar Gamez, J. et al. Mutational analysis of the Cu/Zn superoxide dismutase gene in a Catalan ALS population: should all sporadic ALS cases also be screened for SOD1? J. Neurol. Sci. 247, 21–28 (...
MicroRNAs (miRNA) are short 21-23 nt sequences that regulate gene expression post-transcriptionally [1, 2]. Two processes, mRNA destabilization and translational repression, are believed to occur as a result of miRNA targeted gene regulation [3]. Many miRNA target prediction strategies rely on se...
Meanwhile, an activated SlWIND1 binds the promoter of the REF1 precursor gene to activate its expression, thereby amplifying REF1 signaling for tissue repair and organ regeneration. The study also found that the application of REF1 has dramatically improved regeneration ability and transformation effic...
1A). Clusters were annotated based on the gene expression of cell type-specific markers. A total of 21 single-cell clusters were revealed by a t-SNE plot (Fig. 1B). We focused on clusters of LSECs (cluster 0, 1, 5, 12, 17; Fig. 1B, C) characteristically expressing Cd31 and ...
Furthermore, according to the results of the transcriptome data and weighted gene coexpression correlation network analysis (WGCNA) analysis, phenylalanine ammonia-lyase (PAL3) was considered a key structural gene. The qRT-PCR analysis verified that the PAL3 was highly expressed in SD treated ...
Furthermore, GO and KEGG analyses indicated that the treatment of hepatitis B by YZHG might be related to positive regulation of transcription, positive regulation of gene expression, the hepatitis B pathway and the viral carcinogenesis pathway. Network pharmacology intuitively shows the multicomponent,...
Transcription factors essential for the regulation of gene expression by interacting with transcription corepressor/enhancer complexes and they orchestrate downstream signal transduction. Deregulation of transcription factors is a frequent occurrence in CRC, and the accompanying drastic changes in gene expression...
The phenotype-based methods aim at analysing phenotypic responses, such as gene expression profiles in cell lines or proteomic information, but may neglect valuable information from other types of data sources [6]. Perhaps, any method used alone will have its own short board, so the combination ...