Folic acid (FA) is composed of a pteridine ring, p-aminobenzoic acid and glutamate moieties. Separately, the three moieties have no vitamin activity. Folate deficiency can lead to increased risk of several pathologies. FA is known to be a sensitive compound, easily degraded by pH, light, ...
In metabolism of homocysteine,folic acid is an important cofactor.That decreased enzyme activity is the main agent of causing hyperhomocysteine.Hyperhomocysteine is one of the risk factors of cardiovascular and cerebrovascular disease,lower homocysteine can effectivelly decrease the risk of cardiovascular ...
The folic acid antagonists enjoy a unique place in cancer chemotherapy (Holland, 1961). Aminopterin was the first designed antimetabolite which provided significant regression of a neoplasm, acute lymphocytic leukemia in children (Farber et al., 1948). Nearly ten years ago, in October 1955, ...
we mutated them individually and tested their effects on the transport activity in HEK293F cells (Fig.2g; Supplementary Fig.S1b). Substitutions of Glu123, Arg133, Tyr281, and Arg373 with alanine abolished the transport activity of SLC19A1, consistent with their participation in the...
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1981 . Studies of the mechanism of action of asulam in plants. II. Effect of asulam on the biosynthesis of folic acid. Pestic. Sci 12: 330 – 338 . ,Veerasekaran et al., " Studies of the mechanism of action of asulam in plants. Part II: Effect of asulam on the biosynthesis of ...
Folic acid Folic acid may decrease the excretion rate of Fluconazole which could result in a higher serum level. Fomepizole Fluconazole may decrease the excretion rate of Fomepizole which could result in a higher serum level. Fondaparinux Fluconazole may decrease the excretion rate of Fondaparinux whic...
Folic acidWhey protein isolateDecompositionProtectionMechanismProteins have been widely used to prepare effective carriers for the protection of bioactive components. There were rare studies on proteins' change during protection and its impact on the protection, albeit they are important for the choosing ...
CEM/MTX-low folate (LF) cells, derived by a gradual deprivation of folic acid from 2.3 μm to 2 nm (LF) in the cell culture medium of CEM/MTX cells, resulted in a >20-fold overexpression of a structurally altered RFC...会议名称: Investigators Meeting on MTA, A Novel Multitargeted ...
Folic acid The risk or severity of adverse effects can be increased when Folic acid is combined with Fluorouracil. Fomepizole The metabolism of Fluorouracil can be decreased when combined with Fomepizole. Fondaparinux The risk or severity of bleeding can be increased when Fondaparinux is combined with...