The intersection of drugs and disease targets was determined, and Cytoscape 3.7.2 software was used to construct a "drug-diseasetarget pathway" network. The Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database was used to construct a target protein interaction network, ...
A pleiotropic drug resistance transporter in Nicotiana tabacum is involved in defense against the herbivore Manduca sexta: ABCG5/PDR5 is involved in herbivore resistance. Plant J. 2012;72(5):745–57. Article CAS PubMed Google Scholar Bliss FA, Arulsekar S, Foolad MR, Becerra V, Gillen ...
In contrast, increased expression of the ATP-dependent efflux pump ABCB1 (MDR1), which encodes the membrane drug transporter P-glycoprotein, is a well-described resistance mechanism for doxorubicin, paclitaxel and related taxane drugs (Shen et al, 1986; Fojo et al, 1987; Parekh et al, 1997...
通过TCMSP数据库查询获得了104种化学成分,按口服生物利用度(oral bioavailability,OB≥30%)和类药性(drug-likeness ,DL≥0.18)筛选出15种符合条件的化合物,将其作为候选化合物,结果见表1。 Tab.1 Candidate ingredients ofPiper longumL. 表1 荜茇候选成分 1.3 潜在靶点预测与查询 根据所获得的有效成分,从PharmMapp...
(http://www.swisstargetprediction.ch/) databases to obtain the targets of the ginsenosides. It be recorded when the predicted target probability > 0.1. Due to some ginsenosides had too many targets, such as ginsenoside 20(R)-Protopanaxatriol (PPT) had 94 targets. Too many targets will...
In conclusion, GNPs-PPTT could effectively induce apoptosis in glioma cells and reverse TMZ resistance, thereby, indicative of a promising treatment strategy for GBM. 展开 关键词: drug resistance glioblastoma photothermal therapy gold nanoparticles temozolomide ...
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Drug resistancePeptoidsAmphipathicAntimicrobialsAntimicrobial peptides are thought to be promising antibiotic substitutes for a variety of multidrug-resistant bacteria. Nevertheless, there are several issues with their clinical and commercial development, such as the high cost of peptide manufacturing and the...
11. This single-stranded sulfur incorporation is predicted to be attributed to the nicking activity of SspB, which has not yet been detected for any one of the Dnd proteins8. Notably, SspABCD coupled with SspE confers resistance to a wide array of phages through unusual mechanisms: (1) SspE...
H. Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 15, 1541–1553, doi: 10.1002/(SICI)1097-0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K [pii] 10.1002/(SICI)1097- 0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K (...