Resistance DevelopmentSchematic presentation of multiple diverse molecular mechanism of microbial resistancedoi:10.1007/978-3-319-48683-3_3Shilpa RaySusmita DasMrutyunjay SuarNature Public Health Emergency CollectionHayes JD and Wolf CR (1990) Molecular mechanism of drug resistance. Biochem J 272:281-...
Figure 8: Inhibitor binding and the mechanism of drug resistance. Full size image Given the anchoring role played by the pyridone, we believe that all known inhibitors of PRC2 with the pyridone group essentially have the same binding mode. Significant structural and sequence differences between the...
including relatively low antiviral activity, requiring high doses, a lower genetic barrier for drug resistance, and a short in vivo half-life [16]. Entry inhibitors with novel mechanisms of action and greater convenience
k, Cryo-EM density validation and close-up view of the ATPase dimer interface. l, Residues in the GajA Toprim active site. m, Metal coordinating residues in the BpOLD active site. Extended Data Fig. 2 The effect on phage resistance and DNA cleavage activity of GajA mutations. a, ...
The purpose of this study was to reveal more about the mechanism of the cytotoxic effect of Panax notoginseng on prostate cancer (PCa) cells. Methods Ethanol extract of Panax notoginseng root was authenticated using high-performance liquid chromatography (HPLC). The cytotoxic activity of this herb ...
Experimental results point towards a SMART (Soft Membranes Adapt and Respond, also Transiently) mechanism of action, suggesting that the peptide can be developed as a topical antibacterial agent for treating drug-resistant Staphylococcus aureus infections. Graphical abstract Download: Download high-res ...
Multidrug resistance 1; Nuclear factor κ-B; Puerarin Abstract Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy and its inhibition is an effective way to reverse cancer drug resistance. In the present study, we investigated that puerarin, a natural isoflavonoid from Pueraria lo...
Printed in the Netherlands.Translational regulation as a novel mechanism for the development ofcellular drug resistanceJohn C. Schmitz, Jun Liu, Xiukun Lin, Tian-min Chen, Wu Yan, Ningwen Tai, Ashwin Gollerkeri and Edward ChuDepartment of Medicine and Pharmacology, Yale Cancer Center, Yale ...
A drug delivery device has a cartridge holder adapted to receive and hold a cartridge, the cartridge holder having a receiving and a holding state. The device further comprises a drive assembly with a
influence of temperature regulation center of the set point upward adjustment of body temperature caused by increased. At present that the temperature rise in the height of fever is a positive and negative result of the interaction of two regulatory mechanisms, namely, elevated body temperature regula...