DRUG resistance in bacteriaDRUG resistanceSULFONAMIDE drugsFOSFOMYCINThe sulfonamides (sulfas) are the oldest class of antibacterial drugs and inhibit the bacterial dihydropteroate synthase (DHPS, encoded byfolP), through chemical mimicry of its co-substratep-aminobenzoic acid (pABA). Resistance to ...
Enterobacteriaceae bacteria are important pathogens causing nosocomial infections and foodborne outbreaks. With the wide use of carbapenem antibiotics around the world, resistance to carbapenems among Enterobacteriaceae bacteria is gradually acquired as well as corresponding reports about the resistance. In this...
In environments characterized by extended multi-stress conditions, pathogens develop a variety of immune escape mechanisms to enhance their ability to infect the host. The capsules, polymers that bacteria secrete near their cell wall, participates in numerous bacterial life processes and plays a crucial...
Class 1 integron is widespread in Gram-negative isolates which are causing nosocomial infection.Drug resistance is more liable to horizontal transfer via class Ⅰ integron along with plasmid.It implies the necessary for surveillance of horizontal transfer of antibiotic resistance gene among bacteria genus...
Objective To investigate the characteristics of strains of AmpCβ-lactamase(AmpC enzyme) production in pathogenic bacteria in blood stream and clinical presentations of the cases,and study the related ampC and ampD genes. Methods One hundred and eighty-one strains of gram negative bacillus in blood...
Worldwide, resistance to antibiotics is on the rise. In order to understand why bacteria are becoming immune to previously well-functioning drugs, scientists are penetrating ever deeper into the molecular structure of cells. A research group at Martin Lu
Worldwide, resistance to antibiotics is on the rise. In order to understand why bacteria are becoming immune to previously well-functioning drugs, scientists are penetrating ever deeper into the molecular structure of cells. A research group at Martin Lu
Rapid antibiotic resistance in bacteria is putting pressure on both existing therapies as well as the development pipeline. Here, the authors present a dual-acting anti-virulence treatment that evades antibiotic resistance mechanisms and remains effective against Top Priority pathogens. Christopher Jonkergou...
antibiotics Article Design of Antimicrobial Peptides with Cell-Selective Activity and Membrane-Acting Mechanism against Drug-Resistant Bacteria Seong-Cheol Park 1,† , Hyosuk Son 1,2,†, Young-Min Kim 1,†, Jong-Kook Lee 1, Soyoung Park 1, Hye Song Lim 3, Jung Ro Lee 3,* and Mi...
Here we show that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate the production of highly deleterious hydroxyl radicals in Gram-negative and Gram-positive bacteria, which ultimately contribute to cell death. We also show, in contrast, that ...