12、oachesTargeting virulence factorsOther strategies to overcome antibiotic resistanceBacteriophageNon-antibioticsThe search for new antibiotics監測台灣細菌抗藥性嚴重度與分佈情形 1998年成立台灣微生物抗藥性監測計畫(Taiwan Surveillance of Antimicrobial Resistance, TSAR)偵測對象為:醫院門診及住院病人所分離出的細菌...
(may negatively impact on quality of patient care) Increased cost Higher mortality EMERGING DRUG RESISTANCE IN COMMUNITY PATHOGENS EMERGING RESISTANT PATHOGENS: COMMUNITY HIV: Multiple agents Pneumococcus: Penicillin/cephalosporins, erythromycin Group A streptococcus: Erythromycin Mycobacterium tuberculosis: INH,...
Lack of knowledge of drug spectrum, dosing etc. Lack of knowledge of adverse drug reactions and resistance associated with antibiotics Lack of access to diagnostic facilities Lab, radiology Lack of access to expert advice Diagnostic uncertainty “Shoot first, ask questions later” Why are antibiotics...
抗生素处方(英文PPT)Antibiotic Prescribing AntibioticPrescribing DrJohnFerguson(IDPhysician)DrRobertPickles(IDPhysician)KellyCairns(IDPharmacist)TheAntibioticResistanceSpiral RESISTANCE crosstransmission resistance SELECTION dosageduration BROAD-SPECTRUMEMPIRICTHERAPY Adaptedfrom:J.Carlet.CONCERN newantibiotics (promotion...
AntibioticOveruse&ResistanceCarolynBrayApril11,2006SponsoredBy:Dr.CraigHoesleyINTRODUCTION•Antimicrobialresistanceinthecommunity.•Penicillin-resistantStreptococcuspneumoniae•Pediatrics:Physician&ParentAntibioticPerceptions•Pharmacotherapy:Canwekeepupwithbacterialdrugresistance?•UABMicrobialResistance2005•Combativestr...
抗生素(英文精品) PPCP’s, PBT’s, POP’s PUBS Antibiotic Resistance幻灯片课件.ppt,教学课件课件PPT医学培训课件教育资源教材讲义The reasons for increased resistance are expressed in this simple equation. Let’s look at the first term, Bacteria, first. And
Alteration of drug target 5. Loss of enzymes involved in drug activation (B) Plasmid or transposon mediated: 1. REDUCED PERMEABILITY/UPTAKE Outer membrane porin mutations (crossresistance): Neisseria gonorrhoeae porin mutation cause resistance to penicillin and tetracycline; Enterobacter aerogenes porin ...
•Whenthediagnosisisuncertain,antibioticsareoftenprescribed…–StewardshipstrivestofinetuneantibioticRxinregardsto •Efficacy•Toxicity•Resistance-induction•C.difficile-induction•Cost•Discontinuation HowdoesitrelatetoMRSA?•Resistance-induction:MRSAandotherMDRSs –Darwinism •Flemming•Weinstein,L...
there are few unique antibiotic targets Outline Introduction Untoward Effects of Antibiotics Antibiotic Stewardship Principles of Antibiotic Selection Tenets of Appropriate Antibiotic Use Conclusion Untoward Effects of Antibiotics Antibiotic resistance Adverse drug events (ADEs) Hypersensitivity/allergy Drug side ef...
•Severalmechanismshaveevolvedinbacteriawhichconferthemwithantibioticresistance.Thesemechanismscaneither:1-chemicallymodifytheantibiotic,renderitinactive.2-Physicalremovalfromthecell,3-Ormodifytargetsitesothatitisnotrecognizedbytheantibiotic.4-Preventionofpenetrationofdrug AntibioticResistanceinBacteria Whyisitimportant?...