Mechanism of induction of rat hepatic CYP2B and 3A by the pesticide methoxychlor. J Biochem Mol Toxicol 1998;12: 315-23.Li, H.C., Kupfer, D., 1998. Mechanism of induction of rat hepatic CYP2B and 3A by the pesticide methoxychlor. Journal of Biochemical and Molecular Toxicology 12, 315...
We had previously found that combined treatment with isopentanol and ethanol synergistically induced CYP2H protein and activity in cultured chick nepatoytes. Here we investigated the mechanism of induction of CYP2H by the alcohols and whether they caused a coordinate induction of 5-aminolevulinate ...
Previously, we showed that CYP1A1 expression can be induced by omeprazole (OP) in the human cell line HepG2, but not in the mouse cell line Hepa-1. Now we show induction of CYP1A1 by alpha-naphthoflavone (alphaNF) in Hepa-1 cells. This induction was inhibited by the tyrosine kinase...
Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. predicted by a mathematical model describing the induction of CYP2E1, the main enzyme catalyzing NAPQI formation, by a mechanism of enzyme stabilization. Co... KE Thummel,JT Slattery,H Ro,... - 《Clinical ...
Ugt1a1 induction by taxol significantly increased (~2.5 fold) upon treatment with TAK-242 but it did not affect the induction of Cyp3a11 and Cyp2b10 by taxol. The results indicate that TLR4 has a role in regulating expression of Ugt1a1 by taxol in vitro. Thus TLR4 may mediate drug ...
Phytophthora root rot caused by the oomycete Phytophthora capsici is the most devastating disease in pepper production worldwide, and current management strategies have not been effective in preventing this disease. Therefore, the use of resistant variet
CYP450 3A4 substrate Non-substrate 0.8245 CYP450 1A2 substrate Non-inhibitor 0.94 CYP450 2C9 inhibitor Non-inhibitor 0.9584 CYP450 2D6 inhibitor Non-inhibitor 0.9665 CYP450 2C19 inhibitor Non-inhibitor 0.9634 CYP450 3A4 inhibitor Non-inhibitor 0.9602 CYP450 inhibitory promiscuity Low CYP Inhibitory...
(e.g.zp2.1, vtg1, cyp19a1aandbmp15) in male gonads compared to female gonads. Contrary to expectations, we found highly differential expression of colour pattern (CP) genes in the gonads, suggesting the ‘neofunctionalisation’ of those genes in the zebrafish reproduction system. However, ...
glomerulus, distal tubule, collecting tubule and Bowman capsule in kidney, COUP-TFII modulates renal formation as well as initiation and progression of various renal diseases. This review summarized the latest advances of COUP-TFII in renal development, renal tumor, acute renal injury and renal ...
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor MetS metabolic syndrome MCDD methionine choline-deficient diet CYP4A cytochrome P450 4A VNN1 vanin-1 ALMS1 Alstrom syndrome 1 HFD high-fat diet ALT alanine aminotransferase APO-E2 apolipoprotein-E2 ROS reactive oxygen speci...