The emergence and spread of antimicrobial resistance is far outpacing the development of new therapies 1-3 threatening to thrust medicine into a post-antibiotic era4. Many mechanisms of antimicrobial action and of antimicrobial resistance remain poorly understood as drug development struggles to keep ...
antimicrobial-resistance of the A.Hydrophila strains was highly related to the antimicrobial usage in the field,from where the pathogens were isolated.By analyzing the correlation between the plasmid and its host bacterium's antimicrobial-resistance,it was found that 11 out of the 12 bacteria ...
Broiler feedlots may represent an important source of ARGs in the environment. However, the prevalenc... LY He,YS Liu,HC Su,... - 《Environmental Science & Technology》 被引量: 81发表: 2014年 Antibiotic resistance genes in the environment Antibiotic resistance and its spread in bacteria are...
Due to the spread of antibiotic-resistant strains of Neisseria gonorrhoeae, existing treatments for gonorrhea, the sexually transmitted infection caused by the bacterium, are no longer effective. In the absence of a vaccine, there is an urgent need to develop novel treatment options. "It's becomin...
mechanism, philosophical theory about the nature of organic systems, holding that organisms are machines in the sense that they are material systems. Mechanism seeks to explain biological processes, including behavior, within the framework of classical physics and chemistry. The mechanistic approach has ...
Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled hydrolysis of nucleotides, enabling orga
multiple pathogen clones in patients lead to faster antimicrobial resistance (AMR), rather than the evolution of new resistance mutations in a single strain, challenging traditional AMR perspectives. The study proposes that interventions focusing on preventing bacteria spread could more effectively combat ...
Antimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA identification is relatively laborious. Here, we developed a sim...
The disruption can be transient in the case of cell-penetrating peptides and permanent in the case of antimicrobial peptides [31]. Among these, cell-penetrating peptides and the lipid- or polymer-based carriers possess favorable transmembrane efficiency and the latter possesses relatively...
22 July 2016 Anaerobic Digestion of Dairy Manure Wei Sun, Xun Qian, Jie Gu, Xiao-Juan Wang & Man-Li Duan Animal manure comprises an important reservoir for antibiotic resistance genes (ARGs), but the variation in ARGs during anaerobic digestion at various temperatures and its underly...