With increasing antibiotic resistance and drug safety concerns, novel therapeutics are urgently needed. Antimicrobial peptides are promising candidates that could address the spread of multidrug-resistant patho
The increasing problem of antimicrobial resistance has attracted the public’s attention for more than a decade [1]. Serious health complications can be caused by infections with antimicrobial-resistant bacteria [2,3,4], whose rapid evolution has been accompanied by the slowed development of antibiot...
An Oxford University study has found that multiple pathogen clones in patients lead to faster antimicrobial resistance (AMR), rather than the evolution of new resistance mutations in a single strain, challenging traditional AMR perspectives. The study proposes that interventions focusing on preventing bac...
Microbial infection and cancer are two leading causes of global mortality. Discovering and developing new therapeutics with better specificity having minimal side-effects and no drug resistance are of an immense need. In this regard, cationic antimicrobial peptides (AMP) with dual antimicrobial and ant...
Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled hydrolysis of nucleotides, enabling orga
The spread of antibacterial resistance (Cantas et al., 2013) coupled with side effects associated with the current multidrug TB treatment regimes mean the need to develop new anti-TB agents is of growing importance. For this reason, a better knowledge of the mechanisms of drug resistance and ...
Antimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA identification is relatively laborious. Here, we developed a sim...
, Handbook of Antimicrobial Resistance, 149-173, Springer New York, New York, NY (2017) Google Scholar [26] M.N. Nalam, A. Ali, M.D. Altman, G.S. Reddy, S. Chellappan, V. Kairys, A. Ozen, H. Cao, M.K. Gilson, B. Tidor, T.M. Rana, C.A. Schiffer Evaluating the ...
OPEN SUBJECT AREAS: ANTIMICROBIALS ANTIMICROBIAL RESPONSES Received 3 September 2014 Accepted 24 February 2015 Published 30 March 2015 Correspondence and requests for materials should be addressed to K.B. (srikartik. baruah@ugent.be) Probing the protective mechanism of poly-ß-hydroxybutyrate against ...
However, the emergence and ongoing spread of drug resistance has seriously affected the prevention and control of coccidiosis. Maduramycin is a highly potent member of the class of coccidiostats, which are polyether ionophorous compounds (ionophores). It has been widely used to control coccidiosis...