Ferroptosis is a form of iron-dependent cell death caused by a disorder of iron lipid metabolism.Its mechanism mainly includes lipid metabolism and iron metabolism, which are complicated and strictly regulated by various metabolic and signaling pathways.Current studies have shown that ferroptosis is ass...
coli. Additionally, PPT showed low toxicity to hRBCs and kidney cell lines. Furthermore, the microscopic examination has shown that peptoid has the potential to damage the cell membranes of E. coli. Overall, the easier synthesis and potent antimicrobial activity makes PPT a suitable candidate ...
pneumoniae have been susceptible to penicillin, to the β-lactams group in general, and to other antimicrobial drugs. However, due to the global emergence of resistant and multidrug-resistant strains and the fact that, in many cases, the disease can progress quickly before introduction of ...
antibiotics Article Design of Antimicrobial Peptides with Cell-Selective Activity and Membrane-Acting Mechanism against Drug-Resistant Bacteria Seong-Cheol Park 1,† , Hyosuk Son 1,2,†, Young-Min Kim 1,†, Jong-Kook Lee 1, Soyoung Park 1, Hye Song Lim 3, Jung Ro Lee 3,* and Mi...
Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have reached clinical trials, to date not many have ...
The need for new antibacterial agents is due in part to the increasing resistance of bacteria to known antibiotics, but also due to the desire to increase the drug potency while reducing side effects [24]. Therefore, scientists aim to develop a broad acting antimicrobial agent which will reduce...
Interestingly, increasing the number of D-amino acid substitutions produced a trend of an increase in the values of the MIC and IC50 values, respectively, indicating a decrease in antimicrobial and anticancer activity. Moreover, the same number of amino acid substitutions on the polar face of ...
molecules Article Optimization, Nature, and Mechanism Investigations for the Adsorption of Ciprofloxacin and Malachite Green onto Carbon Nanoparticles Derived from Low-Cost Precursor via a Green Route Rasmiah S. Almufarij 1, Babiker Y. Abdulkhair 2,* , Mutaz Salih 3, Haia Aldosari 4 and ...
Pathways Animesh Mandal 1, Deepak Bhatia 2 and Anupam Bishayee 3,* 1 Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA; animandal0@gmail.com 2 Department of Pharmacogenomics, Bernard ...
Epidemiology of drug resistance: Implications for a post-antimicrobial era. Science 1992, 257, 1050–1055. [CrossRef] [PubMed] 4. Tomasz, A. Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University Workshop. N. Engl. J. Med. 1994, 330, 1247–1251. [Cross...