The mechanism of action of this drug is not fully elucidated. It is suggested that amitriptyline inhibits the membrane pump mechanism responsible for the re-uptake of transmitter amines, such as norepinephrine and serotonin, thereby increasing their concentration at the synaptic clefts of the brain La...
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.6 It was first patented in 19572 and received its initial US...
immunologic perspective that divides breast cancer into four subtypes: luminal A, luminal B, HER2-positive, and triple-negative, based on estrogen (ER), progesterone (PR), and human epidermal growth factor (HER2) [4].Depending on the type of breast cancer, different types of medications are ...
Objective. To investigate the main pharmacological basis and mechanism of action of Gujiansan in the treatment of steroid-induced avascular necrosis of the femoral head (SANFH). Methods. The active c...
According to the degree value, the top active ingredients and action targets were screened. The pharmacodynamic basis of BZYQ in treating CFS was analyzed. 2.8. Molecular docking Some results from Section 2.6 were verified by molecular docking. The crystal structures of Interleukin-6 (IL-6), ...
Pathophysiology of hypertension Hypertension is a complex condition and understanding its pathophysiology has implications for treatment and delay of complications. Baroreflex through the action of stretch receptors on carotid sinus and aorta, provides a negative feedback loop that regulate blood pressure. ...
Laan, Adrie C.Peters, Godefridus J.Nucleosides Nucleotides & Nucleic AcidsBijnsdorp IV, Schwendener RA, Schott H, Fichtner I, Smid K, Schott S et al (2007) In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine. Nucleosides ...
14.The Critic and Promotion of the Remedy Mechanism of the Action Against Unjustice;我国见义勇为法律救济机制的检讨与完善 15.A legal perspective on relief mechanism for adverse drug reactions.;完善我国药品不良反应救济机制的法律思考 16.The Characteristic and Selection of the Model of GPA Remedy Sy...
Mechanism of action Finasteride acts as a competitive and specific inhibitor of Type II 5α-reductase, a nuclear-bound steroid intracellular enzyme primarily located in the prostatic stromal cell that converts the androgen testosterone into the more active metabolite, 5α-dihydrotestosterone (DHT).1 ...
Intravenous injection of a therapeutic dose of propofol produces hypnosis rapidly with minimal excitation, usually within 40 seconds from the start of an injection (the time for one arm-brain circulation). Mechanism of action The action of propofol involves a positive modulation of the inhibitory ...