Hayford points to several benefits of ombud-based ADR: "It provides a confidential, typically low-key approach to dispute resolution that keeps conflicts 'in the family.'.…Properly effected, the ombuds mechanism can do much to enhance the perception that the company is concerned and eager to ...
Therefore, there is an urgent need for elucidation of mechanism(s) underlying drug resistance in AML. In the present study, we found that AML cells showed less susceptibility to adriamycin (ADR) in the presence of hypoxia, while inhibition of hypoxia‐inducible factor 1α (HIF‐1α) by CdCl...
The mechanism through which these meanings seem to arise is pragmatic implicature (cf. Michael 2014: 187). In this sense we observe a fundamental asymmetry between the semantic and pragmatic status of M and R: in R, indexicals are primarily conditioned by grammatical rules that are specific to...
Multimechanism oral dosage forms fabricated by three dimensional printing. J control release. 2000;66:11–17. Guvendiren, Molde MJ, Soares RMD, Kohn J. Designing biomaterials for 3D printing. ACS Biomater Sci Eng. 2016;2:1679–1693 Goyanes A, Fina F, Martorana A, Sedough D, Gaisford S...
Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive factor in understanding and managing DHR. Three mechanisms can be ...
Menstrual disturbance and hypersecretion of progesterone in women with congenital adrenal hyperplasia due to 21‐hydroxylase deficiency SummaryOBJECTIVE While menstrual disturbance is often quoted as a feature of congenital adrenal hyperplasia (CAH), little is known about the mechanism of t... D. J. ...
Targeting the allosteric site within the regulatory EED subunit of PRC2, may offer a novel and unique angle to be advantageous to, or complementary to, directly targeting the SAM competition mechanism of EZH2 or PRC2. Therefore, targeting EED represents a highly attractive strategy for the ...
Palmer et al., “Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization,” EMBO Journal 17, 1598-1605, 1998. Pinkney et al., “The Thiol-Activated Toxin Streptolysin ...
Therefore, there is an urgent need for elucidation of mechanism(s) underlying drug resistance in AML. In the present study, we found AML cells showed less susceptibility to ADR in the presence of hypoxia, while inhibition of HIF by CdCl2 can make AML cells re﹕usceptibility to ADR even ...
569,870. Addressing-machines; gripper mechanism. ADREMA, Ltd., -and SANDERSON, T. E. F. Dec. 9, 1943, No. 20586. [Class 100 (ii)] A gripper device for feeding sheets or formes step-by-step through addressing- or listing- machines is mounted on a bracket 1 adjustably secured to ...