glucagon‐like peptide‐1 receptor agonistglycaemic controlmechanism of actionsemaglutideWhat is known and objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the preferred approved treatment options for people with type 2 diabetes (T2D) and inadequate glycaemic control. The ...
A drug’s mechanism of action may refer to its effects on a biological readout such as cell growth, or its interaction and modulation of its direct biomolecular target, for example a protein or nucleic acid. Latest Research and Reviews A bitopic agonist bound to the dopamine 3 receptor ...
Both G protein and arrestin pathways of GLP-1R can be activated by N-terminally truncated GLP-1 or EX4 that are fused to the receptor Peptide hormones are agonists of class B GPCRs that induce the receptors to recruit either stimulatory G proteins (Gs), leading to elevation in intracellular...
Thus, depending on the agonist, activation of MOR could lead to heterologous desensitization and probable crosstalk between MOR and other Gαi-coupled receptors such as the CB1 receptor. 展开 关键词: Molecular biology Cellular biology Pharmacology Agonist-dependent mechanism of mu-opioid receptor ...
We propose the hypothesis that certain can become constitutively activated during agonist stimulation so that the receptor remains active even after the agonist is removed. This new paradigm of receptor regulation may account for some long term effects of neurotransmitters and hormones. We have tested ...
Sand fly saliva contains maxadilan, a peptide that causes vasodilation and modifies the secretion of pro-inflammatory cytokines by macrophages. We show that 1 to 10 μg maxadilan protected BALB/c mice against a lethal dose of LPS. Maxadilan reduced serum levels of TNF-α by ...
of two structurally similar agonist–antago-nist ligand pairs. Ligands were docked to the empty ORL1receptor (with and without the third intracellular loop, IC3)in different orientations, and the resulting complexes weremonitored during molecular dynamics simulation in orderto see how the subtle ...
The lack of effective understanding of the pain mechanism of McCune–Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. This pape
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, autophagy, and pyrodeath. This distinct pattern
Advances in Digestive MedicineGastroprotective effect of bezafibrate a peroxisome proliferator activated receptor agonist and its mechanism in a rat model of ... L Saha,A Bhatia,A Chakrabarti - 《Advances in Digestive Medicine》 被引量: 1发表: 2016年 Gastroprotective effect of bezafibrate, a peroxiso...