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[12] Noyan-Ashraf, M.H., Momen, M.A., Ban, K., Sadi, A.M., Zhou, Y.Q., Riazi, A.M., et al. 2009. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 58:975-983. [13] Nikolaidis, L.A.,...
glucagon‐like peptide‐1 receptor agonistglycaemic controlmechanism of actionsemaglutideWhat is known and objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the preferred approved treatment options for people with type 2 diabetes (T2D) and inadequate glycaemic control. The ...
7、echanisms of GLP-1 receptor agonists in improving diabetic cardiovascular disease. Keywords: GLP-1 receptor agonist,Type 2 diabetes, Cardiovascular disease,Diabetes complications,Mechanism of actio 综综综综 述述述述 3 GLP-1 受体激动剂对受体激动剂对受体激动剂对受体激动剂对 2 型糖尿病心血管保护...
The GLP-1 receptor agonists class comprises seven compounds/preparations with a similar mode of action. • GLP-1 receptor agonists differ with respect to pharmacokinetic properties, duration of action, and clinical effectiveness. • Plasma glucose is lowered by effects on insulin and glucagon secre...
[53] Meloni AR,DeYoung MB,Lowe C,et al.GLP-1receptor acti- vated insulin secretion from pancreaticβ-cells:mechanism and glucose dependence.Diabetes Obes Metab,2013,15:15-27. [54] Campbell JE,Drucker DJ.Pharmacology,Physiology,and Mecha- nisms of Incretin Hormone Action.Cell Metab,2013,7:...
2型糖尿病;心血管事件;钠葡萄糖协同转运蛋白2抑制剂;胰高血糖素样肽-1受体激动剂 Research advance in SGLT2 inhibitor combined with GLP-1 receptor agonist in the treatment of type 2 diabetes with cardiovascular disease ZHAO Zhe, YANG Dandan, ZHAN Xiaorong (Third Department of Endocrinology, First ...
Mechanistically, GLP-1 can lower BP through a diuretic mechanism, and other effects on the kidneys [39, 40]. At another level, GLP-1RAs also improve systemic insulin sensitivity to lower arterial hypertension in T2DM by decreasing the concentration of angiotensin II (Ang II) [41, 42]....
Brain activity profiling of GLP-1–MK-801 Encouraged by the transcriptomic data indicating that the weight loss is evoked through a mechanism of action involving the combined pharmacological actions of NMDA receptor antagonism and GLP-1 receptor agonism in the hypothalamus, we performed a comprehensive...