Cornell S. A review of GLP-1 receptor agonists in type 2 diabetes: A focus on the mechanism of action of once-weekly agents. J Clin Pharm Ther. 2020 Sep;45 Suppl 1(Suppl 1):17-27. Shah M, Vella A. Effects of GLP-1...
*Graduate School of Tianjin Medical University, Tianjin 300070,China 关键词: β细胞; 抗糖尿病药物; GLP-1; 胰岛素分泌; 2型糖尿病 Keywords: β cells; Anti diabetic drugs; GLP-1; Insulin secretion; Type 2 diabetes mellitus DOI: 10.3760/cma.j.issn.1673-4157.2015.01.017 摘要: 2型糖尿病的主...
The results of this analysis are consistent with the glucose-dependent mechanism of action of liraglutide compared to the glucose?independent mechanism of action of glimepiride * * EOT Table 14.2.6-1 * LEAD-6及其延长研究对比了同为基于GLP-1的T2DM治疗药物利拉鲁肽和艾塞那肽的疗效、安全性及其他...
The results of this analysis are consistent with the glucose-dependent mechanism of action of liraglutide compared to the glucose?independent mechanism of action of glimepiride * * EOT Table 14.2.6-1 * LEAD-6及其延长研究对比了同为基于GLP-1的T2DM治疗药物利拉鲁肽和艾塞那肽的疗效、安全性及其他...
7、echanisms of GLP-1 receptor agonists in improving diabetic cardiovascular disease. Keywords: GLP-1 receptor agonist,Type 2 diabetes, Cardiovascular disease,Diabetes complications,Mechanism of actio 综综综综 述述述述 3 GLP-1 受体激动剂对受体激动剂对受体激动剂对受体激动剂对 2 型糖尿病心血管保护...
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans[ J]. Diabetes, 2011, 60(5): 1561-1565. 9. Shaefer CF Jr, Kushner P, Aguilar R. User's guide to mechanism of action and clinical use of GLP-1 receptor agonists[ J]. Postgrad Med, ...
[11] Coward RJ,Welsh GI,Yang J,et al.The human glomerular podocyte is a novel target for insulin action[J].Diabetes,2005,54(11):3095-3102. [12] De Cosmo S,Menzaghi C,Prudente S,et al.Role of insulin resistance in kidney dysfunction: insights into the mechanism and epidemiological evid...
与GLP-1受体表达相一致的是GLP-1也可以抑制胰高血糖素分泌、胃排空和食物摄入,同时通过神经机制(neural mechanism)增强对葡萄糖的降解。需要注意的是,跟其它胰岛素分泌反应相同,GLP-1对葡萄糖分泌的作用是胰高血糖素依赖性,而由于低血糖作用而引起反调节释放(counter-regulatory release of glucagon)的胰高血糖素作用...
Encouraged by the transcriptomic data indicating that the weight loss is evoked through a mechanism of action involving the combined pharmacological actions of NMDA receptor antagonism and GLP-1 receptor agonism in the hypothalamus, we performed a comprehensive comparison between GLP-1–MK-801 and the...
GLP-1 receptor agonists and DPP4 inhibitors have more advantages than other anti-diabetes drugs because they act on a new target. They will be a useful new class of anti-diabetes drugs. 【Key words】 Diabetes mellitus; Glucaon-like peptide-1; Glucaon-like peptide-1 receptor agonists; ...