A., Tortorella, C., Trejter, M. 2003. Exendin-4, a GLP-1 receptor agonist, stimulates pituitary-adrenocortical axis in the rat: Investigations into the mechanism(s) underlying Ex4 effect. Int J Mol Med 12:237-241.
Currently available drug therapies such as thiazolidinediones (TZD; insulin sensitizers), sulphonylureas, and insulin (insulin secretagogue) have a major drawback that includes hypoglycemia and weight gain due to an insulin-dependent mechanism of action [2]. Oral intake of glucose secretes more ...
glucagon‐like peptide‐1 receptor agonistglycaemic controlmechanism of actionsemaglutideWhat is known and objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the preferred approved treatment options for people with type 2 diabetes (T2D) and inadequate glycaemic control. The ...
[22] Ratner, R.E., Rosenstock, J., Boka, G., Investigators, D.R.I.S. 2010. Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with Type 2 diabetes inadequately controlled with metformin: a randomiz...
[37] Eng, C., Kramer, C.K., Zinman, B., Retnakaran, R. 2014. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Lancet 384:2228-2234. ...
[7] Malendowicz, L.K., Nussdorfer, G.G., Nowak, K.W., Ziolkowska, A., Tortorella, C., Trejter, M. 2003. Exendin-4, a GLP-1 receptor agonist, stimulates pituitary-adrenocortical axis in the rat: Investigations into the ...
2型糖尿病;心血管事件;钠葡萄糖协同转运蛋白2抑制剂;胰高血糖素样肽-1受体激动剂 Research advance in SGLT2 inhibitor combined with GLP-1 receptor agonist in the treatment of type 2 diabetes with cardiovascular disease ZHAO Zhe, YANG Dandan, ZHAN Xiaorong (Third Department of Endocrinology, First ...
[22] Ratner, R.E., Rosenstock, J., Boka, G., Investigators, D.R.I.S. 2010. Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with Type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebocontrolled trial. Diabet Med...
[12]Noyan-Ashraf, M.H., Momen, M.A., Ban, K., Sadi, A.M., Zhou, Y.Q., Riazi, A.M., et al. 2009. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 58:975-983. ...
本期特邀北京大学第一医院霍勇教授带您从GLP-1对损伤后心脏功能的影响、心脏代谢功能的影响、心率/血压的影响等方面探寻其心血管保护作用的机制。一些研究报告称,急性或慢性GLP-1R激动作用导致啮齿动物血压升高…