Deciphering the mode of action of drug is an important and crucial process in novel drug discovery. The understanding of antimicrobial resistance mechanisms in pathogens is a vital task during drug development. In these aspects, proteomics provides an innovative platform for the understanding of ...
Because of the associated risks, clindamycin should be reserved for serious infections for which the use of less toxic antimicrobial agents are inappropriate.15 Clindamycin is active against a number of gram-positive aerobic bacteria, as well as both gram-positive and gram-negative anaerobes.14 ...
Antimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA identification is relatively laborious. Here, we developed a sim...
Cefotaxime sodium, a parenteral cephalosporin antibiotic, exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Chemical structure modifications have enabled this compound to be resistant to the action of Richmond I, III, IV, and V β-lactamase enzymes. Excellent activity ...
/ International Journal of Antimicrobial Agents 32 (2008) 199–206 203 Fig. 3. Reduction of invasive pneumococcal diseases in the USA since introduction of the conjugate vaccine. 7. Efficacy of the pneumococcal conjugate vaccine [22], as this generation exhibits the highest mortality with respect ...
This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer ...
Herein, we characterized a novel antimicrobial peptide called Pinipesin, present in the exuviae extract of the centipede. The antimicrobial activity of Pinipesin was tested. The haemolytic activity of the peptide was evaluated and its possible mechanism of action was investigated. Identification was ...
This situation has brought attention to other antimicrobial agents like antimicrobial peptides (AMPs), for being considered an alternative to conventional drugs. These compounds target bacterial membranes for their activity, which gives them a broad spectrum of action and less probable resistance ...
- 《Antimicrobial Agents & Chemotherapy》 被引量: 293发表: 2010年 Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Hepatitis C affects approximately 3% of the world population, yet its current treatment options are limited to interferon-ribavirin drug ...
The importance of biostimulants, defined as plant growth-promoting agents that differ notably from fertilizers, is increasing steadily because of their pot