(4)体外Th17极化实验中,MDSC显著促进Th17细胞的分化,SLE患者来源的MDSC较HC来源的MDSC促Th17分化能力更强,MDSC的促Th17分化作用依赖于Arg-1;MDSC可上调CD4+T细胞内GCN2,磷酸化e IF2α,m TOR和RORγt的表达,加入Arg-1抑制剂可抑制上述分子的表达,提示MDSC促Th17分化作用与Arg-1下游GCN2-e IF2α,m TOR信号...
1. Tumor MDSCs会上调Cat2,促进L-arg吸收,导致细胞外L-arg减少,从而抑制T细胞 2. 微粒体(microsomal) PGES1促进肺转移,通过SDF-1/CXCR4调控MDSCs 3. 抑郁诱发的NE会促进M-MDSC招募-->TAM和IL6释放,从而激活前列腺癌的STAT3通路 4. Enzalutamide增加的MDSC的抑制性,通过抑制MDSC的线粒体呼吸通路 ...
早期研究发现,肿瘤患者体内累积大量 MDSCs,可通过产生活性氧 (reactiveoxygenspecies,ROS)、精氨酸酶(arginase,ARG)-1 和诱导型一氧化氮合酶 (induciblenitricoxidesynthase,iNOS)等因子有效地抑制 T 细胞功能,导致患者免疫功 能低下,促进肿瘤细胞免疫逃逸。然而,越来越多的研究发现,感染、肥胖和自身免疫 病等多种...
The proportion of monocytic MDSCs population, the inhibitory effect of MDSCs on T-cell proliferation, the levels of STAT3 phosphorylation, and the expression of functional molecules (Arg-1 and IL-10) in MDSCs were all decreased in T. gondii-infected pregnant Tim-3 ...
The advent of immunotherapy represents a significant breakthrough in cancer treatment, with immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 demonstrating remarkable therapeutic efficacy. However, patient responses to immunotherapy vary sign
TGF-Beta enhances immunosuppression of myeloid-derived suppressor cells to induce transplant immune tolerance through affecting arg-1 expression Front Immunol, 13 (2022) Google Scholar [26] B. Dewidar, C. Meyer, S. Dooley, et al. TGF-Beta in hepatic stellate cell activation and liver fibrogenesi...