MDA-MB-468是研究基底样TNBC基因表达和调节、抑制细胞生长存活信号通路中常用模型,与非三阴性乳腺癌相比,TNBC对激素和人表皮生长因子受体2(HER2)靶向治疗表现出更强的耐药性。MDA-MB-468为上皮细胞样,贴壁生长,部分细胞呈松散附着的圆形形态,可以从培养瓶内脱离。微观可观察到典型的桥粒、微绒毛和不规则多核特征。
三阴性乳腺癌(Triple-negative breast cancer,TNBC)是雌激素受体(Estrogen receptor,ER),孕激素受体(Progesterone receptor,PR)和人表皮生长因子受体2(Human epidermal growth factor receptor 2,HER2)表达均呈阴性的一类乳腺癌,具有侵袭能力强,转移率高,预后差的特性.由于TNBC缺乏特定的靶向治疗药物,且复发率高,导致...
另两个家庭成员也有这个突变; 一个同卵双生姐妹也患有乳腺癌。这株细胞有一个后天的TP53突变, 而其野生型等位基因丢失; 一个PTEN基因的后天的纯合缺失, 以及多个与乳腺癌发病机理相关的位点上发生的杂合突变。这株细胞Her2-neu和p53表达都呈阴性。 Ishikawa细胞系;细胞传代方法:1:3传代,3-4天换液一次;细胞形态...
在裸鼠皮下接种10^7个MDA-MB-468细胞，肿瘤在21天内发生频率可达100%。这些细胞也是转染宿主，用于乳腺癌和免疫肿瘤学研究。MDA-MB-468细胞是研究基底样TNBC基因表达和调节、抑制细胞生长存活信号通路的常用模型。它们表现出对激素和HER2靶向治疗的更强耐药性。MDA-MB-468细胞为上皮细胞样，贴壁生长，呈...
TNBC cell line has no expression of estrogen receptor (ER), progesterone receptor (PR), and enriched human epidermal growth factor receptor 2 (HER2). MDA-MB-468 highly expressed glucose-6-phosphate dehydrogenase (G6PD). MDA-MB-468 presents basal-like tumors of TNBC and epithelial-like ...
供GC法含量间甲酚101153-201001常温,避光100mgERBB2重组狗 HER2 / ErbB2 蛋白 (His 标签) Protein雄激素受体抗体 Anti-AR 0.1ml 供GC法含量对甲酚101154-2010012-8℃,密封100mgIL11RA重组狗 IL11RA / IL-11RA / IL11Rα 蛋白 (His 标签) ProteinARC抗体 Anti-ARC 0.2ml ...
Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic... PURPOSE: The Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancers and plays an important role in small ce...
Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells Zimmer B,et al.Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells.Neoplasia... Timo,Fal...
Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced breast cancers having the poorest prognoses. The morbidity and mortality associated with advanced disease, as well as the emergence of multi-drug resistant...
Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced breast cancers having the poorest prognoses. The morbidity and mortality associated with advanced disease, as well as the emergence of multi-drug resistant...