雷公藤红素促进人类乳腺癌MDA-MB-453细胞HER2蛋白降解及诱导凋亡的机制
Therefore, this study was intended to analyze the effects of fisetin on HER2/neu-overexpressing breast cancer cell lines. Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its...
MDA—MB-231和MDA—MB-453细胞系都是一种三阴性乳腺癌细胞系,其没有表达雌激素受体、孕激素受体和人表皮生长因子受体2(HER2)受体,因此难以通过内分泌治疗和靶向治疗来治疗。在伊班膦酸钠的作用下,这些细胞系的增殖能力显著降低,细胞增殖曲线明显下降。 此外,伊班膦酸钠还能够诱导MDA—MB-231和MDA—MB-453细胞的凋...
乳腺癌目前已经成为第一位威胁女性健康的恶性肿瘤,其中原癌基因HER-2/neu过度表达类型的乳腺癌约占30%。此类乳腺癌对传统化疗药物存在明显耐药,常导致化疗失败。HER-2/neu编码的蛋白为跨膜型人表皮生长因子受体家族成员,具有内在的酪氨酸蛋白激酶(proteintyrosinekinase,PTK)活性,有报道HER-2/neu高表达乳腺癌的化疗抗...
免疫荧光检测HER2蛋白在细胞中的定位变化.[结果]雷公藤红素对MDA-MB-453有强大的细胞毒作用,IC50为(5.22±0.29)μmol/L;该化合物可浓度依赖性地诱导MDA-MB-453细胞发生凋亡,出现典型的凋亡小体、sub-G1改变及细胞凋亡相关蛋白Caspase-3、Parp的裂解活化.值得一提的是,雷公藤红素作用后,Western Blot检测到HER2...
The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic a... Increased lipogenesis and protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression and is under intense...
The aim of this study was to examine the expression of Lin28A and androgen receptor (AR) in ER−/Her2+ breast cancer, and to research the association of ... Honghong,Shen,Yong,... - 《Breast Cancer Research & Treatment》 被引量: 5发表: 2016年 Abstract 1775: Scope of cell cycle ...
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The major snagfaced by the human population is the development of chemoresistance to HER2 inhibitors by advanced stage breast cancer cells. Moreover, recent researchers focussed on fisetin as an antiproliferative and chemotherapeutic agent. Therefore, this study was intended to analyze the effects of ...
The major snagfaced by the human population is the development of chemoresistance to HER2 inhibitors by advanced stage breast cancer cells. Moreover, recent researchers focussed on fisetin as an antiproliferative and chemotherapeutic agent. Therefore, this study was intended to analyze the effects of ...