FULL PAPER British Journal of Cancer (2015) 113, 773–785 | doi: 10.1038/bjc.2015.267 Keywords: VEGF isoforms; metastasis; colonisation; breast cancer MDA-MB-231 breast cancer cells overexpressing single VEGF isoforms display distinct colonisation characteristics Melanie Di Benedetto*,1,2,7, Aurore...
In general, AQEAC showed a poor cytotoxic effect on breast cancer cell lines with IC50 values more than 300 μg/mL on both breast cancer cell lines (Table 1). Fig. 2 Cell survivability (%) of MCF-7 breast cancer cell line following treatment with HEAC, EAEAC and AQEAC extracts for 7...
(a) MDA-MB 231 cell line, (b) MCF-10A cell line, and (c) DOX cytotoxicity comparison in both cell lines. DOX: doxorubicin. Full size image The IC50 for nrCap18 on MDA-MB 231 was approximately 0.29 μg/ml, while this value for MCF-10A was 5.53 μg/ml. The IC50 of the ...
Moreover, this cell line constitutively expresses both α5(β1) and (αv)β3 integrins. Download: Download high-res image (641KB) Download: Download full-size image Fig. 2. Gene expression of alpha 5 (ITGA5) and beta 3 (ITGB3) integrins in small-hairpin RNA knock-down MDA-MB-231 ...
The current study further investigates the cellular anticancer activities of an S. crispus subfraction (SCS) and its ability to modulate tamoxifen-induced effects on the breast cancer cell lines, MCF-7 and MDA-MB-231, as well as the non-cancerous breast epithelial cell line, MCF-10A....
Full size imageDiscussion A previous study had reported that ethanolic extract of P. amaryllifolius was able to selectively inhibit 50% of cell viability on estrogen independent MDA-MB-231 but not estrogen dependent MCF-7 breast cancer cell line [13]. This study was aimed to understand the re...
While in line with these observations, our findings further suggest that the differential susceptibilities to the cytotoxic effects of curcumin may be highly associated with the SKP2-Cip/Kips (p21 and p27) pathway, as observed in both cell lines, and that the deregulation of SKP2 and p21/p...
Download: Download full-size image Fig. 1. OLE inhibits specifically MDA-MB-231 and OVCAR-3 cell viability, without affecting non-tumoral cells. Short-term effect of OLE on HCEpiC (a), MDA-MB-231 (b), and OVCAR-3 (c) cell viability. HCEpiC, MDA-MB-231, and OVCAR-3 cells were ...
Full size image It seems from Table2that there is a direct correlation between the toxicity of SNPs and ASNPs and proliferation rate of treated cells. This may be rationalized in the following way: First, the highest cytotoxicity was seen for the most aggressive cell line with higher proliferat...
Na2HPO4produces phosphate ion in the form of HPO42−, i.e. hydrogen phosphate. Effect of hydrogen phosphate (HPO42−) on MDA-MB-231 and THP-1 cell viability In order to further examine the effect of hydrogen phosphate (HPO42−) on viability of MDA-MB-231 and THP-1 cells, cells ...