FULL PAPER British Journal of Cancer (2015) 113, 773–785 | doi: 10.1038/bjc.2015.267 Keywords: VEGF isoforms; metastasis; colonisation; breast cancer MDA-MB-231 breast cancer cells overexpressing single VEGF isoforms display distinct colonisation characteristics Melanie Di Benedetto*,1,2,7, Aurore...
HEAC and EAEAC showed weak cytotoxic effect (IC50 > 100–1000 μg/mL) on MDA-MB-231. For AQEAC, the IC50 value against MCF-7 was more than 1000 μg/mL and MDA-MB-231 was 347.44 ± 98.78 μg/mL indicating that AQEAC has poor cytotoxic effect against breast cancer. In...
In this study, we investigated the toxicity of different phosphate compounds to triple-negative human breast cancer cells (MDA-MB-231) and to human monocytes (THP-1). We demonstrated that, unlike phosphate in the form of dihydrogen phosphate (H2PO4−), hydrogen phosphate (HPO42−) induces...
Download: Download full-size image Fig. 4. Integrin knock-down MDA-MB-231 cells migrating on IGDQ-exposing surfaces (post-transduction passage 5): alpha 5 integrin (A, B, C) and beta 3 integrin subcellular localizations (D, E, F). Immunofluorescence labeling of alpha 5 integrin (ITGA5 ...
MDA-MB-231 is one of the highly invasive and metastatic human breast cancer cell lines [14], [15]. It is often used to study the migration of breast cancer and to screen anti-invasion drugs in treating breast cancer [16]. So, we choose human breast cancer cells MDA-MB-231 to detect...
The aims of this study is to examine the concentration- and time-related effects of curcumin on two different breast cancer cells, MCF-7 and MDA-MB-231, and investigated the functional changes induced by curcumin treatment, as well as their relationship to the PI3K/Akt-SKP2-Cip/Kips pathway...
amaryllifolius treatment for 48 and 72 hr were found to induce apoptosis on MDA-MB-231 cells. Apoptosis or programmed cell death is a distinctive form of cell death exhibiting specific morphological and biochemical characteristics [16]. Biochemical changes occurring in mitochondria and cytoplasm ...
crispus[11], reported to induce apoptosis of MDA-MB-231 cells[29] and increase caspase-8 activity in MCF-7 and MDA-MB-231 cells in association with elevation of Fas protein expression[30]. Alternatively, caspase-8 cleaves BH3-only protein, Bid, to generate the truncated form of Bid, t...
Triple negative breast cancer (TNBC), ~ 10–20% of diagnosed breast cancers, metastasizes to brain, lungs, liver. Iodine nanoparticle (INP) radioenhancers specifically localize to human TNBC MDA-MB-231 tumors growing in mouse brains after iv inject
Comparing the IC50 values of nrCap18 and DOX in MDA-MB 231 and MCF-10A cell lines. DOX: doxorubicin. ns P > 0.05 and **P < 0.01. DOX: doxorubicin. Full size image Selectivity of nrCap18 for cancer cells The selectivity of nrCap18 for cancer cells (MDA-MB 231) was invest...