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The efficiency of targeted therapy for triple-negative breast cancer (TNBC) MDA-MB-231 cells, which lack the expression of estrogen receptor (ER), Progesterone receptor (PgR) and human epidermal growth factor receptor-2 (HER2), is limited. In this study,...
The MDA-MB-231 cell is a triple-negative breast cancer cell line that does not express estrogen receptor, progesterone receptor, or HER2 protein, making therapies for this type of cancer difficult19. Because treatment of triple-negative breast cancer cells is challenging, we focused on ...
Fig. 8. Effects of melatonin (MLT) and ortho-topolin riboside (oTR) on Wnt/β-catenin target gene expression in MDA-MB-231/RR cells. MLT: melatonin; oTR: ortho-topolin riboside. 4. Discussion TNBC is characterized by the absence of ER, PR, and HER2, which are targets for highly effec...
Results: TNF-α reduced proliferation and enhanced apoptosis in MCF-7, which was opposite in the MDA-MB231 cell line. Additionally, TNF-α increased ASM expression in MCF-7, as well as ceramide. In MDA-MB231, both ASM and SPHK1 protein level were increased, but ceramide decreased. Bcl-...
MEKK2 was required for epidermal growth factor receptor and Her2/Neu activation of ERK5, with ERK5 being required for metastasis. Loss of MLK3 expression increased mitotic infidelity and apoptosis in vitro. Knockdown of MEKK2 and MLK3 resulted in increased apoptosis in orthotopic xenografts relative ...
Western blot analysis confirmed MDA-MB-231, MCF7, and ZR-75-1 cells as triple-negative, ER-positive and HER2-positive cell lines, respectively (Supplementary Fig. 1). MTT assay showed that both MCF7 (Supplementary Fig. 2a) and ZR-75-1 (Supplementary Fig. 2b) display a drastic loss in...
HOXB8 and HOXB9 expression profiles in cell lines extensively used in the literature addressing the putative role of HOXB genes in breast cancer (MCF7, BT474, SKBR3, MDA231 and MDA468) and representative of the clinical breast cancer molecular subtypes (Luminal A, Luminal B, HER2+ and Tripl...
Treatments with VDR agonists for 72 h markedly decreased the expression levels of KCa1.1 transcripts and proteins in MDA-MB-453 cells, resulting in the significant inhibition of depolarization responses induced by paxilline, a specific KCa1.1 blocker. The specific proteasome inhibitor MG132 suppressed ...
(C–E) MDA-MB-231 cells (C–E) and MDA-MB-468 cells (F) were transfected with the intraluminal Ca2+ dye, GEM-CEPIA1er, and at the day of the experiments upon confirmation of the positive Ca2+ dye expression by the cells (D), the cells were maintained in a Ca2+-free HBS medium...