and the dysfunction of MCM2 was correlated with the progression and poor prognoses of malignant tumors. According to the altered expression of MCM2 and its correlation with clinicopathological features of cancer patients, MCM2 was thought to be a sensitive biomarker ...
CerbB.2andBRCA--linBreastCancer ABSTRACT objective:Breast caneerisoneofthe malignant tumorswitht11e highest incidenceforfemaleanddoseseriousharmto women’Shealthforit's incidenceis becominghigher and higher.Thedevelopment and progression of breast cancer which ...
Journal of Experimental & Clinical Cancer Research (2020) 39:225 Page 12 of 16 (Fig. 8a-d, Supplementary Fig. 2A-B). In conclusion, miR-195-5p/497–5p could inhibit the stem-like proper- ties of CCSCs by targeting MCM2. miR-195-5p/497–5p could restrict tumorigenesis and stem-like...
The top three up-regulated MCMs were MCM2, MCM6 and MCM8, which were up-regulated 4.57-, 3.11- and 2.79-fold in HCC relative to noncancerous liver, respectively. These data indicate that MCM2–7, MCM8 and MCM10 mRNA levels increase in HCC, and are candidate drivers of ...
There, you will see that it really is not too difficult with a little training to differentiate cancer from benign tissue, to differentiate epithelial cells from fibroblasts and from blood vessels. And you will see that just by being able to differentiate the nucleus, the nuclear membrane, the...
Inhibition of DDK activity causes apoptosis in cancer cells, but not in normal cells, and therefore Cdc7 is seen as an attractive therapeutic target. Indeed, crystal structures of the human Cdc7 core in complex with small conserved regions of Dbf440,41 have led to a number of drug discovery...
4Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom. 5Present address: Institute of Molecular Biology (IMB) gGmbH, Ackermannweg 4, Mainz, Germany. e-mail: m.reuter@imb-mainz.de; chris....
Stem cells including cancer stem cells undergo asymmetric cell divisions (Morrison and Kimble, 2006). During the asymmetric division of Drosophila male germ cells, which is an extreme case, it has been shown that the daughter cell harboring “stemness” properties will receive mostly parental (H3...
MCM7 Colorectal cancer (CRC) PAK2 miR-107 1. Introduction Colorectal cancer (CRC) is a common malignant tumor in both men and women worldwide. In the last few decades, there has been an increasing number of CRC patients[1], [2], especially in developed countries[3], [4], [5], [...
Primers used for cloning, mutagenesis, and sequencing are provided in Supplementary Table1. cDNA vectors encoding WT, CH (primase dead, polymerase competent), and AxA (catalytic dead) PRIMPOL proteins were described before27and kindly provided by Dr. Juan Méndez (The Spanish Cancer Research ...