K. ( 1993 ) Cell cycle regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins , Genes & Dev. 7 , 2149 – 2160 .Yan H , Merchant AM and Tye BK ( 1993 ) Cell cycle regulated nuclear localization of MCM...
MCM proteins are downregulated and dissociated from chromatin when cells exit the cell cycle. MCM proteins are upregulated frequently in a variety of dysplastic and cancer cells. To delineate the role of MCM in esophageal epithelial biology, we determined the MCM family gene expression during the ...
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during rep...
微小染色体维持缺陷蛋白2(MCM2)重组蛋白 别名: BM28; CCNL 1; CCNL1; CDC like 1; cdc19; CDCL 1; CDCL1; Cell devision cycle like 1; Cyclin like 1; D3S3194; DNA replication licensing factor MCM2; KIAA0030;
4E). The results showed that compare with control, RUNX1 knockdown down-regulated the expression of CDC20 and MCM2 genes which promote cell cycle progression. Then CHIP-qPCR experiments were performed on the enriched genes, and the results showed a significant difference in the enrichment ...
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neig...
Objective: We examined cell cycle and cell death biomarker trends with the normal-dysplasia-carcinoma sequence of the oral epithelia analyzing the patholog... I Kodani,K Shomori,M Osaki,... - 《Pathobiology》 被引量: 114发表: 2001年 Correlation between expression of metallothionein and expression...
The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed ...
MCM2, also named CDCL1 and BM28, is a human nuclear protein that plays an important role in 2 crucial steps of the cell cycle, namely, onset of DNA replication and cell division. Properties Storage Instructions All the reagents are stored at 2-8°C. The kit is stable for 6 months ...
MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. MCM2 has been mapped to 3q21. From its ...